RAG1/2 induces double‐stranded DNA breaks at non‐Ig loci in the proximity of single sequence repeats in developing B cells
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350958
Abstract: In developing B cells, V(D)J gene recombination is initiated by the RAG1/2 endonuclease complex, introducing double‐stranded DNA breaks (DSBs) in V, D, and J genes and resulting in the formation of the hypervariable parts of… read more here.
Keywords: stranded dna; double stranded; developing cells; rag1 ... See more keywords
Developing cells remember where they came from, thanks to keratin filaments.
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DOI: 10.1038/d41586-020-02443-w
Abstract: Filaments of keratin — stable protein polymers best known for their function in hair and nails — provide a memory of cell polarity at a crucial stage in early mouse development. A role for keratin… read more here.
Keywords: thanks keratin; came thanks; keratin filaments; remember came ... See more keywords