Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex
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DOI: 10.1038/s41598-017-15253-4
Abstract: The ventricular zone (VZ) of the developing cerebral cortex is a pseudostratified epithelium that contains progenitors undergoing precisely regulated divisions at its most apical side, the ventricular lining (VL). Mitotic perturbations can contribute to pathological… read more here.
Keywords: shape; cerebral cortex; developing cerebral; spindle length ... See more keywords
Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals
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DOI: 10.1371/journal.pbio.3001563
Abstract: The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate only glutamatergic… read more here.
Keywords: competence; cells respond; developing cerebral; cortical cells ... See more keywords
mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22116034
Abstract: Dysregulated mammalian target of rapamycin (mTOR) activity is associated with various neurodevelopmental disorders ranging from idiopathic autism spectrum disorders (ASD) to syndromes caused by single gene defects. This suggests that maintaining mTOR activity levels in… read more here.
Keywords: cerebral cortex; developing cerebral; cholesterol; mtor ... See more keywords