The effect of levomepromazine on the healthy and injured developing mouse brain – An in vitro and in vivo study
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DOI: 10.1016/j.ibror.2020.09.003
Abstract: Highlights • Levomepromazine (LMP) does not induce cell death in the healthy developing brain.• Excitotoxic lesion size and apoptosis are unaffected by LMP.• Body weight gain is reduced in mouse pups receiving higher-dose LMP treatment.•… read more here.
Keywords: effect levomepromazine; developing mouse; injured developing; healthy injured ... See more keywords
Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain
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DOI: 10.1016/j.neures.2020.12.004
Abstract: Doublecortin-like kinase 1 (DCLK1) is a Doublecortin family kinase involved in a range of brain development processes including cell migration, axon/dendrite growth, and synapse development. The Dclk1 gene potentially generates multiple splicing isoforms, but the… read more here.
Keywords: developing mouse; dclk1 isoforms; dclk1; mouse brain ... See more keywords
Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
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DOI: 10.1111/jnc.15505
Abstract: Corticosteroids are stress-related hormones that maintain homeostasis. The most effective corticosteroids are corticosterone (CORT) in rodents and cortisol in primates. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1; EC 1.1.1.146), encoded by Hsd11b1, is a key regulator of… read more here.
Keywords: dehydrogenase type; hsd11b1; developing mouse; cort ... See more keywords
The distribution of the proteoglycan FORSE‐1 in the developing mouse central nervous system
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DOI: 10.1111/joa.12907
Abstract: Glycosylation is a major post‐translational modification in which a carbohydrate known as a glycan is enzymatically attached to target proteins which regulate protein folding and stability. Glycans are strongly expressed in the developing nervous system… read more here.
Keywords: system; nervous system; developing mouse; proteoglycan forse ... See more keywords
Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain
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DOI: 10.7554/elife.61408
Abstract: 3D imaging data necessitate 3D reference atlases for accurate quantitative interpretation. Existing computational methods to generate 3D atlases from 2D-derived atlases result in extensive artifacts, while manual curation approaches are labor-intensive. We present a computational… read more here.
Keywords: imaging data; developing mouse; anatomical boundaries; mouse ... See more keywords