Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase
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DOI: 10.1038/s41598-017-01756-7
Abstract: The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety… read more here.
Keywords: analog; rna cap; methyltransferase; development adenosylmethionine ... See more keywords