Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove
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DOI: 10.1172/jci.insight.156643
Abstract: Targeted biologic therapies can elicit an undesirable host immune response characterized by the development of antidrug antibodies (ADA), an important cause of treatment failure. The most widely used biologic across immune-mediated diseases is adalimumab, a… read more here.
Keywords: antidrug antibodies; development antidrug; development; hla peptide ... See more keywords