Development of a Class A/B Hybrid GPCR System for the Proximity-Assisted Screening of GPCR Ligands.
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DOI: 10.1021/acschembio.4c00658
Abstract: Class A G protein-coupled receptors (GPCRs) are key mediators in numerous signaling pathways and important drug targets for several diseases. A major shortcoming in GPCR ligand screening is the detection limit for weak binding molecules,… read more here.
Keywords: system; class hybrid; class; development class ... See more keywords
Progress on the development of Class A GPCR‐biased ligands
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DOI: 10.1111/bph.17301
Abstract: Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs… read more here.
Keywords: progress development; class; development class; class gpcr ... See more keywords