Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-019-09656-1
Abstract: Rare diseases are defined by their numbers. In the United States, a rare disease is defined as one that occurs in less than 200,000 people [1]. In Europe that number is when fewer than 5… read more here.
Keywords: issue; rare diseases; disease; application pharmacometrics ... See more keywords
Theoretical structural characterization of lymphoguanylin: A potential candidate for the development of drugs to treat gastrointestinal disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.02.016
Abstract: Guanylin peptides (GPs) are small cysteine-rich peptide hormones involved in salt absorption, regulation of fluids and electrolyte homeostasis. This family presents four members: guanylin (GN), uroguanylin (UGN), lymphoguanylin (LGN) and renoguanylin (RGN). GPs have been… read more here.
Keywords: gastrointestinal disorders; theoretical structural; lgn; structural characterization ... See more keywords