Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
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DOI: 10.1002/cbic.202200539
Abstract: Tetrazine (Tz)–trans‐cyclooctene (TCO) ligation is an ultra‐fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a 3H‐Tz based synthon would have wide applications for in vitro/ex vivo… read more here.
Keywords: facilitating tritiation; tritiated tetrazine; tetrazine facilitating; tritiation proteins ... See more keywords
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01198
Abstract: The atypical chemokine receptor 3 (ACKR3), formerly known as CXC-chemokine receptor 7 (CXCR7), has been postulated to regulate platelet function and thrombus formation. Herein, we report the discovery and development of first-in-class ACKR3 agonists, which… read more here.
Keywords: discovery development; platelet degranulation; cxcr7; first class ... See more keywords
Development of the first ITER gyrotron in QST
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DOI: 10.1088/1741-4326/ab22c2
Abstract: This paper presents a summary of recent progress pertaining to the manufacturing and inspection of ITER gyrotrons and the operation system in QST. Major achievements are as follows. (i) The final design of the ITER… read more here.
Keywords: iter gyrotron; qst; iter; development first ... See more keywords
Psoriatic arthritis screening by the dermatologist: development and first validation of the ‘PURE‐4 scale’
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14861
Abstract: Dermatologists are recommended to ask psoriasis patients about musculoskeletal complaints to allow early detection and treatment of psoriatic arthritis (PsA). Screening tools have been developed to help identify patients warranting further rheumatologic assessment, but evidence… read more here.
Keywords: psoriatic arthritis; arthritis screening; screening dermatologist; development first ... See more keywords
How the Language of Instruction Influences Mathematical Thinking Development in the First Years of Bilingual Schoolers
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2021.533141
Abstract: The present research study focuses on how the language of instruction has an impact on the mathematical thinking development as a consequence of using a language of instruction different from the students’ mother tongue. In… read more here.
Keywords: mathematical thinking; development first; language; language instruction ... See more keywords