Cypermethrin inhibits Leydig cell development and function in pubertal rats
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23473
Abstract: Cypermethrin is a broad‐spectrum pyrethroid insecticide that is widely used. It may induce adverse endocrine‐disrupting effects on the male reproductive system. Whether cypermethrin can disrupt Leydig cell development and function in the late puberty remains… read more here.
Keywords: leydig cell; cell; development function; cypermethrin ... See more keywords
RelB intrinsically regulates the development and function of medullary thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9298-3
Abstract: Medullary thymic epithelial cells (mTECs) act as one of the major stromal components in the thymus for selection and maturation of both conventional T cells and non-conventional T cells. Extensive efforts have been spent to… read more here.
Keywords: epithelial cells; relb; thymic epithelial; development function ... See more keywords
The development and function of dendritic cell populations and their regulation by miRNAs
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0398-2
Abstract: ABSTRACTDendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs… read more here.
Keywords: immune; dcs; function; development function ... See more keywords
New subtypes of allele-specific epigenetic effects: implications for brain development, function and disease
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2019.04.012
Abstract: Typically, it is assumed that the maternal and paternal alleles for most genes are equally expressed. Known exceptions include canonical imprinted genes, random X-chromosome inactivation, olfactory receptors and clustered protocadherins. Here, we highlight recent studies… read more here.
Keywords: development function; allele specific; brain development; brain ... See more keywords
Experimental models of testicular development and function using human tissue and cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.12.011
Abstract: The mammalian testis has two main roles, production of gametes for reproduction and synthesis of steroid- and peptide hormones for masculinization. These processes are tightly regulated and involve complex interactions between a number of germ… read more here.
Keywords: testis; experimental models; testicular development; function ... See more keywords
Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15069
Abstract: Bcl-3 is an atypical NF-κB family member that regulates NF-κB-dependent gene expression in effector T cells, but a cell-intrinsic function in regulatory T (Treg) cells and colitis is not clear. Here we show that Bcl-3… read more here.
Keywords: elevated levels; treg cells; colitis; function ... See more keywords
TH2 cell development and function
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.118
Abstract: T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, such as asthma and allergy. Here, we… read more here.
Keywords: immunology; cell development; development function; cell ... See more keywords
The role of PQBP1 in neural development and function.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220920
Abstract: Mutations in the polyglutamine tract-binding protein 1 (PQBP1) gene are associated with Renpenning syndrome, which is characterized by microcephaly, intellectual deficiency, short stature, small testes, and distinct facial dysmorphism. Studies using different models have revealed… read more here.
Keywords: neural development; function; role pqbp1; pqbp1 neural ... See more keywords
Ypel5 regulates liver development and function in zebrafish.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad019
Abstract: YPEL5 is a member of the YPEL gene family that is evolutionarily conserved in the eukaryotic species. To date, the physiological function of YPEL5 has not been yet assessed due to a paucity of genetic… read more here.
Keywords: liver development; function; ypel5; development function ... See more keywords
A lysosomal regulatory circuit essential for the development and function of microglia
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp8321
Abstract: As the primary phagocytic cells of the central nervous system, microglia exquisitely regulate their lysosomal activity to facilitate brain development and homeostasis. However, mechanisms that coordinate lysosomal activity with microglia development, chemotaxis, and function remain… read more here.
Keywords: function; development; regulatory circuit; lysosomal regulatory ... See more keywords
The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.668659
Abstract: RNA binding proteins (RBPs) have a broad biological and physiological function and are critical in regulating pre-mRNA posttranscriptional processing, intracellular migration, and mRNA stability. QKI, also known as Quaking, is a member of the signal… read more here.
Keywords: emerging roles; rna binding; cardiovascular development; function ... See more keywords