Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.08.054
Abstract: Prolonged use/abuse of opioid agonists leads to development of severe dependence to these drugs. Orexin-A has a crucial role in development of morphine dependence. The locus coeruleus (LC) is implicated in the expression of morphine… read more here.
Keywords: morphine dependence; dependence; morphine; locus coeruleus ... See more keywords
Inflammatory mediators of opioid tolerance: Implications for dependency and addiction
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2019.01.003
Abstract: Each year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged… read more here.
Keywords: tolerance; morphine; development morphine; pain ... See more keywords
Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00072
Abstract: Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis, cancer,… read more here.
Keywords: tolerance; stress; development morphine; morphine tolerance ... See more keywords