Development of the 5-Nitrosalicaldehyde Arylhydrazones as Anticancer (MCF-7 and HCT116) Agents Targeting Inhibition of VEGFR-2 and Cytokines (IL-6 and TNF-α)
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DOI: 10.1021/acsomega.5c07719
Abstract: A pseudoring replacement strategy has been employed to develop the 3-halogeno-substituted 5-nitrosalicylaldehyde arylhydrazones as potential antibreast (MCF-7) and anticolorectal (HCT116) cancer agents. The mechanism of action of the test compounds was investigated through cell cycle… read more here.
Keywords: development nitrosalicaldehyde; hct116; inhibition; vegfr ... See more keywords