DEVELOPMENT OF NOVEL PRECLINICAL MODELS OF SECONDARY RESISTANCE TO THE PI3KΔ INHIBITOR IDELALISIB IN SPLENIC MARGINAL ZONE LYMPHOMA (SMZL)
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_119
Abstract: rubicin, epirubicin, vinblastine, etoposide, paclitaxel, and topotecan. RTI‐79's PK characteristics are similar to rifabutin and exhibited no overt toxicity in mice at high doses. RTI‐79 did not exacerbate the known cardiotoxicity associated with doxorubicin as… read more here.
Keywords: rti; novel preclinical; secondary resistance; preclinical models ... See more keywords
Design and development of novel N‐(4‐aminobenzoyl)‐ l‐glutamic acid conjugated 1,3,5‐triazine derivatives as Pf‐DHFR inhibitor: An in‐silico and in‐vitro study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23290
Abstract: In the present work, a library of 120 compounds was prepared using various aliphatic and aromatic amines. Finally, 10 compounds were selected through in silico screening carrying 4‐aminobenzoyl‐l‐glutamic acid and 1,3,5‐triazine moiety. The docking results… read more here.
Keywords: design development; silico; development novel; glutamic acid ... See more keywords
Development of a novel five‐lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24172
Abstract: Breast cancer (BC) is an age‐related disease. Long noncoding RNAs (lncRNAs) have been proven to be crucial contributors in tumorigenesis. This study aims to develop a novel lncRNA‐based signature to predict elderly BC patients’ prognosis. read more here.
Keywords: breast cancer; elderly patients; signature; development novel ... See more keywords
Development of a novel MR‐conditional microwave needle for MR‐guided interventional microwave ablation at 1.5T
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29289
Abstract: To develop an MR‐conditional microwave needle that generates a spherical ablation zone and clear MRI visibility for MR‐guided microwave ablation. read more here.
Keywords: conditional microwave; microwave; microwave ablation; development novel ... See more keywords
Development of novel methods to predict the strength properties of thermally treated sandstone using statistical and soft-computing approach
Sign Up to like & getrecommendations! Published in 2017 at "Neural Computing and Applications"
DOI: 10.1007/s00521-017-3233-z
Abstract: The knowledge of thermally modified strength properties is crucial in processes such as underground coal gasification, disposal of radioactive wastes in deep geological reservoirs and restoration of fire-damaged structures. However, due to the unavailability of… read more here.
Keywords: novel methods; strength; methods predict; strength properties ... See more keywords
Development of 19 novel microsatellite markers of lily-of-the-valley (Convallaria, Asparagaceae) from transcriptome sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05376-9
Abstract: The lily-of-the-valley Convallaria (Asparagaceae) consists of three herbaceous perennial species. The plants are commonly found in northern hemisphere, and are best-known for their ornamental and pharmaceutical value. In order to assess the genetic structure, diversity… read more here.
Keywords: valley convallaria; novel microsatellite; convallaria asparagaceae; microsatellite markers ... See more keywords
Development of Novel Material Systems and Coatings for Extreme Environments: A Brief Overview
Sign Up to like & getrecommendations! Published in 2018 at "JOM"
DOI: 10.1007/s11837-018-3273-6
Abstract: The aim of this paper is to briefly analyze different methodologies for development of novel materials systems and coatings for use in extreme environments, with a focus on high-temperature applications in aerospace and aeronautics. The… read more here.
Keywords: material systems; systems coatings; high temperature; development novel ... See more keywords
Development of a Novel Monoclonal Antibody–Based Indirect Competitive ELISA with Immunoaffinity Cleanup for the Detection of Triclosan in Chickens
Sign Up to like & getrecommendations! Published in 2019 at "Food Analytical Methods"
DOI: 10.1007/s12161-019-01644-y
Abstract: Triclosan (TCS) was quantitatively analyzed for the first time in chicken samples using immunoaffinity cleanup followed by indirect competitive enzyme-linked immunosorbent assay (icELISA). Monoclonal antibodies (mAbs) against TCS were prepared. The mAb 6E1 showed high… read more here.
Keywords: detection; immunoaffinity; indirect competitive; immunoaffinity cleanup ... See more keywords
Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-019-00587-w
Abstract: PurposeThe purpose of this study was to investigate the albumin-binding compound 111In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors.Methods111In-C4-DTPA was injected in healthy nude mice for pharmacokinetic and biodistribution… read more here.
Keywords: post injection; dtpa; novel imaging; imaging agent ... See more keywords
Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.011
Abstract: Amyloids are protein aggregates of highly regular structure that are involved in diverse pathologies such as Alzheimer's and Parkinson's disease. Recent evidence has shown that under certain conditions, small peptides can self-assemble into amyloids that… read more here.
Keywords: novel catalytic; metal dependent; amyloid displaying; catalytic amyloid ... See more keywords
Development of a novel 3D glass-ceramic scaffold for endometrial cell in vitro culture
Sign Up to like & getrecommendations! Published in 2018 at "Ceramics International"
DOI: 10.1016/j.ceramint.2018.05.054
Abstract: Abstract Glass-ceramic and biphasic calcium phosphate materials with 3D architectures to be used as scaffolds for endometrial stromal cells (ESCs) were synthesized by freezing and lyophilising ceramic suspensions. The microstructures obtained by FESEM showed the… read more here.
Keywords: glass; ceramic scaffold; glass ceramic; cell ... See more keywords