Advancing Pharmacotherapy Development from Preclinical Animal Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_85
Abstract: Animal models provide rapid, inexpensive assessments of an investigational drug's therapeutic potential. Ideally, they support the plausibility of therapeutic efficacy and provide a rationale for further investigation. Here, I discuss how the absence of clear… read more here.
Keywords: development preclinical; preclinical animal; advancing pharmacotherapy; pharmacotherapy ... See more keywords
Development of Preclinical Models to Understand and Treat Colorectal Cancer
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DOI: 10.1055/s-0037-1602240
Abstract: Abstract The establishment and validation of preclinical models that faithfully recapitulate the pathogenesis and treatment response of human colorectal cancer (CRC) is critical to expedient therapeutic advances in the clinical management of this disease. Integral… read more here.
Keywords: development preclinical; colorectal cancer; preclinical models; understand treat ... See more keywords
Anatomical Variations of the Common Carotid Arteries and Neck Structures of the New Zealand White Rabbit and Their Implications for the Development of Preclinical Extracranial Aneurysm Models
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DOI: 10.3390/brainsci13020222
Abstract: Background: Rabbit models involving neck arteries are of growing importance for the development of preclinical aneurysm models. An optimal understanding of the anatomy is primordial to allow the conception of models while minimizing mortality and… read more here.
Keywords: common carotid; new zealand; aneurysm models; development preclinical ... See more keywords
Development of Preclinical Ultrasound Imaging Techniques to Identify and Image Sentinel Lymph Nodes in a Cancerous Animal Model
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DOI: 10.3390/cancers14030561
Abstract: Simple Summary Bowel cancer is the fourth most common cancer in the UK. Treatment is dominated by major surgery because current imaging modalities cannot accurately determine lymph node involvement or vascular invasion. Although potentially curative,… read more here.
Keywords: cancer; preclinical ultrasound; ultrasound imaging; lymph nodes ... See more keywords
Sustained Elevated Blood Pressure Accelerates Atherosclerosis Development in a Preclinical Model of Disease
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DOI: 10.3390/ijms22168448
Abstract: The continuous relationship between blood pressure (BP) and cardiovascular events makes the distinction between elevated BP and hypertension based on arbitrary cut-off values for BP. Even mild BP elevations manifesting as high-normal BP have been… read more here.
Keywords: development preclinical; blood pressure; model; preclinical model ... See more keywords