EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22896
Abstract: Colorectal cancer (CRC) is a heterogeneous disease with complex mechanisms of pathogenesis. Classification systems have been proposed based on molecular features of tumors in clinical practice. Thus, more molecular markers associated with development and progression… read more here.
Keywords: exosc4; development progression; cell; colorectal cancer ... See more keywords
Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_24
Abstract: Transient receptor potential (TRP) cation channel superfamily plays important roles in a variety of cellular processes such polymodal cellular sensing, adhesion, polarity, proliferation, differentiation and apoptosis. The expression of TRP channels is strictly regulated and… read more here.
Keywords: receptor potential; biology; transient receptor; development progression ... See more keywords
BIO FOr CARE: biomarkers of hypertrophic cardiomyopathy development and progression in carriers of Dutch founder truncating MYBPC3 variants—design and status
Sign Up to like & getrecommendations! Published in 2021 at "Netherlands Heart Journal"
DOI: 10.1007/s12471-021-01539-w
Abstract: Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic heart disease, commonly caused by truncating variants in the MYBPC3 gene. HCM is an important cause of sudden cardiac death; however, overall prognosis is good and penetrance… read more here.
Keywords: mybpc3 variants; hypertrophic cardiomyopathy; development progression; progression ... See more keywords
The role of microRNAs in the development, progression and drug resistance of chronic myeloid leukemia and their potential clinical significance.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120437
Abstract: Chronic myeloid leukemia (CML) is a cancer of the bone marrow characterized by an uncontrolled increase in the production of myeloid cells. MicroRNAs (miRNAs) are a group of non-coding RNA molecules with a length of… read more here.
Keywords: development progression; cml; myeloid leukemia; role ... See more keywords
The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
Sign Up to like & getrecommendations! Published in 2017 at "Surgical oncology"
DOI: 10.1016/j.suronc.2017.07.011
Abstract: More than 100 trillion microorganisms inhabit the human intestinal tract and play important roles in health conditions and diseases, including cancer. Accumulating evidence demonstrates that specific bacteria and bacterial dysbiosis in the gastrointestinal tract can… read more here.
Keywords: development progression; gastrointestinal tract; tract; progression gastrointestinal ... See more keywords
Decreased cell stiffness enhances leukemia development and progression
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0763-7
Abstract: Emerging evidence has linked cell mechanics to functional behaviors [1]. The biophysical traits of a single cell are inextricably linked to the cytoskeleton. It has become increasingly evident that intrinsic and extrinsic mechanical properties, which… read more here.
Keywords: cell; ptpn21; mice; mll af9 ... See more keywords
GCN2: roles in tumour development and progression
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20211252
Abstract: GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as… read more here.
Keywords: gcn2; development; roles tumour; gcn2 roles ... See more keywords
Association of Ocular Antihypertensive Medications and the Development and Progression of Age-related Macular Degeneration in a U.S. Insurance Claims Database
Sign Up to like & getrecommendations! Published in 2020 at "Current Eye Research"
DOI: 10.1080/02713683.2020.1849731
Abstract: ABSTRACT Purpose/Aim: To assess whether ocular antihypertensives are associated with the development and progression of age-related macular degeneration (AMD). Materials and Methods: This retrospective, observational cohort study using healthcare claims data from a U.S. nationwide… read more here.
Keywords: ocular antihypertensive; antihypertensive medications; development progression; amd ... See more keywords
The cancer epigenome: Non‐cell autonomous player in tumor immunity
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15681
Abstract: Dysregulation of the tumor‐intrinsic epigenetic circuit is a key driver event for the development of cancer. Accumulating evidence suggests that epigenetic and/or genetic drivers stimulate intrinsic oncogenic pathways as well as extrinsic factors that modulate… read more here.
Keywords: tumor; immunity; cancer epigenome; development progression ... See more keywords
Mechanisms of development and progression of pancreatic neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13272
Abstract: Pancreatic ductal adenocarcinoma (PDAC) develops via dysplastic changes in the epithelia graded as low‐ and high‐grade with accumulation of molecular alterations. Constitutive activation of mitogen‐activated protein kinase (MAPK) contributed by attenuation of DUSP6 plays a… read more here.
Keywords: development; mechanisms development; progression pancreatic; development progression ... See more keywords
Metformin limits osteoarthritis development and progression through activation of AMPK signalling
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-216713
Abstract: Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. Methods Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein… read more here.
Keywords: dmm surgery; development progression; metformin;