Articles with "development protein" as a keyword



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Improving strategies in the development of protein-downregulation based antiandrogens.

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Published in 2021 at "ChemMedChem"

DOI: 10.1002/cmdc.202100033

Abstract: AR plays a crucial role in the occurrence and development of prostate cancer (PCa) and its signaling pathway remains active in castration-resistant prostate cancer (CRPC) patients. The drug resistance of current clinical used antiandrogens is… read more here.

Keywords: protein; improving strategies; strategies development; downregulation ... See more keywords
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Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.

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Published in 2022 at "Chemical Society reviews"

DOI: 10.1039/d2cs00116k

Abstract: Progress in strategies aimed at breaking down therapeutic target proteins has led to a paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. Our understanding… read more here.

Keywords: thalidomide derivatives; crbn; progress; protein degraders ... See more keywords