Improving strategies in the development of protein-downregulation based antiandrogens.
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DOI: 10.1002/cmdc.202100033
Abstract: AR plays a crucial role in the occurrence and development of prostate cancer (PCa) and its signaling pathway remains active in castration-resistant prostate cancer (CRPC) patients. The drug resistance of current clinical used antiandrogens is… read more here.
Keywords: protein; improving strategies; strategies development; downregulation ... See more keywords
Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.
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DOI: 10.1039/d2cs00116k
Abstract: Progress in strategies aimed at breaking down therapeutic target proteins has led to a paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. Our understanding… read more here.
Keywords: thalidomide derivatives; crbn; progress; protein degraders ... See more keywords