Development of pyrazolo[1,5-a]pyrimidine-based antibacterial agents
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DOI: 10.1080/00397911.2023.2209815
Abstract: Abstract In the present study, a facile method was adopted to efficiently prepare new pyrazolo[1,5-a]pyrimidin-2-amines linked to arene units in good to excellent yields. A mixture of acetophenones and DMF-DMA was heated at 120 oC… read more here.
Keywords: antibacterial activity; based antibacterial; pyrazolo pyrimidine; pyrazolo ... See more keywords
Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives
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DOI: 10.3390/ph15080949
Abstract: Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cellular… read more here.
Keywords: design synthesis; development pyrazolo; pyrazolo pyrimidine; synthesis development ... See more keywords