N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance
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DOI: 10.1007/s13311-021-01116-4
Abstract: Opioids are essential drugs for pain management, although long-term use is accompanied by tolerance, necessitating dose escalation, and dependence. Pharmacological treatments that enhance opioid analgesic effects and/or attenuate the development of tolerance (with a desirable… read more here.
Keywords: development; morphine; tolerance; inhibition ... See more keywords
Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats
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DOI: 10.1016/j.eplepsyres.2018.07.018
Abstract: Tolerance to some therapeutic effects of antiepileptic drugs may account for the development of pharmacoresistance in patients with epilepsy. In the present study, following oral acute pretreatment with the new antiepileptic drug perampanel (0.1, 0.3,… read more here.
Keywords: tolerance; treatment; development tolerance; genetically epilepsy ... See more keywords