The Developmental Gene Hypothesis for Punctuated Equilibrium: Combined Roles of Developmental Regulatory Genes and Transposable Elements
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.201900173
Abstract: Theories of the genetics underlying punctuated equilibrium (PE) have been vague to date. Here the developmental gene hypothesis is proposed, which states that: 1) developmental regulatory (DevReg) genes are responsible for the orchestration of metazoan… read more here.
Keywords: developmental gene; gene hypothesis; developmental regulatory; hypothesis ... See more keywords
Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01679-x
Abstract: Higher-order chromatin organization controls transcriptional programs that govern cell properties and functions. In order for pluripotent stem cells (PSCs) to appropriately respond to differentiation signals, developmental gene loci should be structurally and spatially regulated to… read more here.
Keywords: developmental gene; chromatin; pluripotent stem; stem cells ... See more keywords
Conserved non-coding elements: developmental gene regulation meets genome organization
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1074
Abstract: Abstract Comparative genomics has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree of conservation between two or more organisms, regularly exceeding that found within protein-coding exons. These elements, collectively referred to… read more here.
Keywords: conserved non; gene regulation; developmental gene; elements developmental ... See more keywords
Systematic analysis of the Myxococcus xanthus developmental gene regulatory network supports posttranslational regulation of FruA by C‐signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14249
Abstract: Upon starvation Myxococcus xanthus undergoes multicellular development. Rod‐shaped cells move into mounds in which some cells differentiate into spores. Cells begin committing to sporulation at 24–30 h poststarvation, but the mechanisms governing commitment are unknown.… read more here.
Keywords: myxococcus xanthus; developmental gene; dev; frua ... See more keywords
Diversity of σ66-Specific Promoters Contributes to Regulation of Developmental Gene Expression in Chlamydia trachomatis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bacteriology"
DOI: 10.1128/jb.00310-22
Abstract: Meticulous promoter elucidation is required to understand the foundations of transcription initiation. However, knowledge of promoter-specific transcription remains limited in C. trachomatis. This work underscores the structural and functional plasticity of σ66-specific promoters that are… read more here.
Keywords: promoter; developmental gene; transcription; trachomatis ... See more keywords