PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
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DOI: 10.7554/elife.26952
Abstract: The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan. We show that similar developmental stress is necessary… read more here.
Keywords: extends lifespan; developmental mitochondrial; mitochondrial stress; stress ... See more keywords