Fluoride: no evidence of developmental neurotoxicity due to current exposure levels in Europe
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02823-1
Abstract: Recently, the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) published a comprehensive review article about the possible human developmental neurotoxicity of fluoride (Guth et al. 2020). Fluoride has been added… read more here.
Keywords: exposure levels; epidemiological studies; exposure; current exposure ... See more keywords
A locust embryo as predictive developmental neurotoxicity testing system for pioneer axon pathway formation.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of toxicology"
DOI: 10.1007/s00204-020-02929-6
Abstract: Exposure to environmental chemicals during in utero and early postnatal development can cause a wide range of neurological defects. Since current guidelines for identifying developmental neurotoxic chemicals depend on the use of large numbers of… read more here.
Keywords: navigation; pioneer axon; locust; developmental neurotoxicity ... See more keywords
Does inflammation mediate behavioural alterations in anaesthesia-induced developmental neurotoxicity?
Sign Up to like & getrecommendations! Published in 2022 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2021.12.040
Abstract: Anaesthesia exposure early in life potentially impairs neurobehavioural development. A recent study in the Journal investigated the possibility that progesterone mitigates anaesthesia-induced developmental neurotoxicity in neonatal rats exposed to sevoflurane. The novel findings show that… read more here.
Keywords: induced developmental; anaesthesia induced; behavioural alterations; developmental neurotoxicity ... See more keywords
An in vitro developmental neurotoxicity screening assay for retinoic acid-induced neuronal differentiation using the human NT2/D1 cell line.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.04.005
Abstract: Traditional approaches (e.g., neurobehavior, neuropathology) can detect alterations in apical endpoints indicative of developmental neurotoxicity (DNT). However, there is an increasing desire to understand mode-of-action (MOA) for DNT effects; thus, this short communication describes initial… read more here.
Keywords: differentiation; retinoic acid; developmental neurotoxicity; nt2 cell ... See more keywords
Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.12.007
Abstract: The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or… read more here.
Keywords: adverse outcome; outcome pathway; mdma; developmental neurotoxicity ... See more keywords
Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2019.106813
Abstract: Animal studies have demonstrated that multiple exposures to sevoflurane during the postnatal period lead to impaired synaptogenesis and cognitive deficits in adulthood. However, the underlying mechanisms remain unclear. Histone deacetylase 6 (HDAC6), a unique isoform… read more here.
Keywords: multiple sevoflurane; group; developmental neurotoxicity; histone ... See more keywords
Developmental neurotoxicity of different pesticides in PC‐12 cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.03.027
Abstract: ABSTRACT The detection of developmental neurotoxicity (DNT) of chemicals has high relevance for protection of human health. However, DNT of many pesticides is only little known. Furthermore, validated in vitro systems for assessment of DNT… read more here.
Keywords: gap; neurite outgrowth; transcriptional alterations; dnt ... See more keywords
Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.02.008
Abstract: Currently, the identification of chemicals that have the potential to induce developmental neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic testing of DNT is not a standard requirement within the… read more here.
Keywords: neurotoxicity dnt; dnt; identification; developmental neurotoxicity ... See more keywords
Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Danio rerio)
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00642
Abstract: In recent years, psychedelics have garnered significant interest as therapeutic agents for treating diverse neuropsychiatric disorders. However, the potential for these compounds to produce developmental neurotoxicity has not been rigorously assessed, and much of the… read more here.
Keywords: neurotoxicity screen; screen psychedelics; developmental neurotoxicity; neurotoxicity ... See more keywords
Developmental neurotoxicity of silver nanoparticles: the current state of knowledge and future directions
Sign Up to like & getrecommendations! Published in 2022 at "Nanotoxicology"
DOI: 10.1080/17435390.2022.2105172
Abstract: Abstract The increasing production and use of silver nanoparticles (AgNPs) as an antimicrobial agent in an array of medical and commercial products, including those designed for infants and children, poses a substantial risk of exposure… read more here.
Keywords: knowledge; developmental neurotoxicity; silver nanoparticles; neurotoxicity silver ... See more keywords
International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy211
Abstract: The Organisation for Economic Co-Operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In most regulatory sectors, including the ones dealing with pesticides and industrial chemicals registration, historical use of the… read more here.
Keywords: dnt testing; international regulatory; neurotoxicity; regulatory scientific ... See more keywords