Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010246
Abstract: SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1… read more here.
Keywords: nadase activity; developmental signaling; activity; sarm1 ... See more keywords
Organoids in biliary research: insights into developmental signaling and applications in disease modeling
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1656019
Abstract: The embryonic development of the biliary system is orchestrated by complex signaling pathways, including Notch, TGF-β, Wnt, and GFs, which regulate biliary stem/progenitor cell fate, polarity, and ductal morphogenesis. These pathways not only govern physiological… read more here.
Keywords: disease; signaling pathways; biliary research; developmental signaling ... See more keywords