Developmental toxicity induced by triclosan exposure in zebrafish embryos
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DOI: 10.1002/bdr2.1982
Abstract: The present study aimed to investigate the acute toxicity and the developmental alterations induced by triclosan (TCS) exposure in zebrafish early‐life stages using fish embryo acute toxicity tests as a methodological approach. read more here.
Keywords: developmental toxicity; induced triclosan; exposure zebrafish; toxicity ... See more keywords
Identifying the landscape of developmental toxicity new approach methodologies
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DOI: 10.1002/bdr2.2075
Abstract: The dynamics and complexities of in utero fetal development create significant challenges in transitioning from lab animal‐centric developmental toxicity testing methods to assessment strategies based on new approach methodologies (NAMs). Nevertheless, considerable progress is being… read more here.
Keywords: developmental toxicity; new approach; landscape developmental; toxicity ... See more keywords
Embryo‐fetal developmental toxicity and toxicokinetics of loxoprofen tromethamine intravenously administered to pregnant rats
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DOI: 10.1002/bdr2.2116
Abstract: Loxoprofen tromethamine is a novel structural compound related to loxoprofen. It has been used for the treatment of pain and inflammation. However, the embryo‐fetal developmental toxicity (EFDT) of loxoprofen tromethamine has not been evaluated in… read more here.
Keywords: developmental toxicity; fetal developmental; embryo fetal; toxicokinetics loxoprofen ... See more keywords
Developmental toxicity induced by brodifacoum in zebrafish (Danio rerio) early life stages
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DOI: 10.1002/bdr2.2118
Abstract: The present study mainly focused on the assessment of developmental toxicity induced by exposure to brodifacoum (BDF) in zebrafish at early life stages. read more here.
Keywords: developmental toxicity; early life; life stages; toxicity induced ... See more keywords
The role of receptor‐mediated activities of 4‐ and 5‐ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity
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DOI: 10.1002/jat.4428
Abstract: The present study evaluated the aryl hydrocarbon receptor (AhR), estrogen receptor‐α (ER‐α), and retinoic acid receptor (RAR) mediated activities of nine 4‐ and 5‐ring unsubstituted and monomethylated polycyclic aromatic hydrocarbons (PAHs) using a series of… read more here.
Keywords: developmental toxicity; pahs; ring unsubstituted; receptor ... See more keywords
Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae
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DOI: 10.1002/jat.4599
Abstract: As part of the US Environmental Protection Agency's perfluoroalkyl and polyfluoroalkyl substances (PFAS) Action Plan, the agency is committed to increasing our understanding of the potential ecological effects of PFAS. The objective of these studies… read more here.
Keywords: pfas; perfluoroalkyl polyfluoroalkyl; xenopus laevis; toxicity ... See more keywords
Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster
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DOI: 10.1002/jat.4749
Abstract: N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde,… read more here.
Keywords: reproductive developmental; transgenerational reproductive; toxicity; formaldehyde drosophila ... See more keywords
Developmental toxicity of triclocarban in zebrafish (Danio rerio) embryos
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22289
Abstract: Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using… read more here.
Keywords: toxicity triclocarban; exposure; triclocarban zebrafish; tcc exposure ... See more keywords
Environmental relevant concentrations of triclosan affected developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23448
Abstract: Triclosan (TCS), as a broad‐spectrum antibacterial agent, is widely used in various pharmaceutical and personal care products. However, the details of ecological environmental health risks of TCS are not clear. In this study, zebrafish embryos/larval… read more here.
Keywords: developmental toxicity; apoptosis; tcs; 250 tcs ... See more keywords
Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs.
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DOI: 10.1007/978-1-4939-7883-0_8
Abstract: In vivo pregnant study protocols covering preconceptional exposure as well as prenatal and postnatal development including the lactation period to screen the toxic effects on specific elements of the highly complicated reproductive cycle are time-consuming… read more here.
Keywords: embryo culture; based whole; developmental toxicity; whole embryo ... See more keywords
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
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DOI: 10.1007/s00204-023-03655-5
Abstract: Angiogenesis is a key process in embryonic development, a disruption of this process can lead to severe developmental defects, such as limb malformations. The identification of molecular perturbations representative of antiangiogenesis in zebrafish embryo (ZFE)… read more here.
Keywords: angiogenesis inhibitors; antiangiogenesis; untargeted metabolomics; developmental toxicity ... See more keywords