The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell"
DOI: 10.1016/j.ccell.2018.11.018
Abstract: Summary The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular underpinnings of this transmissible cancer, we combined pharmacological screens with an integrated systems-biology characterization.… read more here.
Keywords: devil facial; stat3; erbb stat3; tasmanian devil ... See more keywords
Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours
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DOI: 10.1098/rsob.220208
Abstract: MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and… read more here.
Keywords: mhc; devil facial; facial tumours; mhc mhc ... See more keywords
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials
Sign Up to like & getrecommendations! Published in 2021 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12451
Abstract: Immune evasion is critical to the growth and survival of cancer cells. This is especially pertinent to transmissible cancers, which evade immune detection across genetically diverse hosts. The Tasmanian devil (Sarcophilus harrisii) is threatened by… read more here.
Keywords: immune evasion; devil facial; tumour; dft1 ... See more keywords