Substrate Determinants for Unwinding Activity of the DExH/D-Box Protein RNA Helicase A.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01025
Abstract: RNA helicase A (RHA) as a member of the DExH/D-box subgroup of helicase superfamily II is involved in virtually all aspects of RNA metabolism. It exhibits robust RNA helicase activity in vitro. However, little is… read more here.
Keywords: substrate determinants; rna helicase; dexh box; rha ... See more keywords
Molecular Basis of RNA-Driven ATP Hydrolysis in DExH-Box Helicases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11980
Abstract: The spliceosome machinery catalyzes precursor messenger (pre-m)RNA splicing. In each cycle, the spliceosome experiences massive compositional and conformational remodeling fueled by the concerted action of specific RNA-dependent ATPases/helicases. Intriguingly, these enzymes are allosterically activated to… read more here.
Keywords: dexh box; rna; atp hydrolysis;
Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein
Sign Up to like & getrecommendations! Published in 2018 at "Nucleus"
DOI: 10.1080/19491034.2017.1364826
Abstract: ABSTRACT The nucleoporin Nup98 has been linked to the regulation of transcription and RNA metabolism,1-3 but the mechanisms by which Nup98 contributes to these processes remains largely undefined. Recently, we uncovered interactions between Nup98 and… read more here.
Keywords: nucleoplasmic nup98; gene expression; nup98; gene ... See more keywords
The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1414949
Abstract: Neurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD), seizures, various… read more here.
Keywords: rna helicases; neurodevelopmental disorders; dexh box; dead dexh ... See more keywords
Targeting Hepatocellular Carcinoma Growth: Haprolid’s Inhibition of AKT Signaling Through DExH-Box Helicase 9 Downregulation
Sign Up to like & getrecommendations! Published in 2025 at "Cancers"
DOI: 10.3390/cancers17030443
Abstract: Simple Summary Haprolid, a novel compound derived from Myxobacterium, has demonstrated selective toxicity against various tumor cells and effectively inhibits the growth of hepatocellular carcinoma. However, its molecular mechanism remains unclear. This study identified DExH-Box… read more here.
Keywords: dexh box; hepatocellular carcinoma; box helicase;