Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04309-y
Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor in children. Interference with the polyamine biosynthesis pathway by inhibition of MYCN-activated ornithine decarboxylase (ODC) is a validated approach. The ODC inhibitor α-difluoromethylornithine (DFMO, or Eflornithine)… read more here.
Keywords: probenecid; activity dfmo; dfmo; antitumor activity ... See more keywords
ETMR-18. TARGETING Lin28 IN ETMR WITH ODC1 INHIBITOR DFMO
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.221
Abstract: Abstract Embryonal tumor with multilayered rosettes (ETMR), is an aggressive brain tumor primarily occurring in young patients ( read more here.
Keywords: etmr; odc1 inhibitor; dfmo; lin28 ... See more keywords
DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-4018
Abstract: Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (AZA) activates type I interferon signaling to increase IFNγ+ T cells and… read more here.
Keywords: ovarian cancer; tumor microenvironment; cancer; dfmo ... See more keywords
Abstract 6725: Targeting urea cycle dysfunction to prevent and treat osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6725
Abstract: Introduction: Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults. Intensive multimodal treatment cures almost 75% of patients who present with localized disease; however, only 25% of patients who… read more here.
Keywords: proliferation; growth; urea cycle; dfmo ... See more keywords
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer
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DOI: 10.3390/ijms221910255
Abstract: Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), has promising activity against various cancers and a tolerable safety profile for long-term use as a chemopreventive agent. However, the anti-tumor effects of DFMO in ovarian… read more here.
Keywords: epithelial ovarian; jnk; treatment; dfmo ... See more keywords