Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression
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DOI: 10.1021/acs.molpharmaceut.7b00787
Abstract: Zirconium-89 is an emerging radionuclide for positron emission tomography (PET) especially for biomolecules with slow pharmacokinetics as due to its longer half-life, in comparison to fluorine-18 and gallium-68, imaging at late time points is feasible.… read more here.
Keywords: dfo zegfr; 2377 affibody; zegfr 2377; affibody bioconjugates ... See more keywords
The Use of a Non-Conventional Long-Lived Gallium Radioisotope 66Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule
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DOI: 10.3390/pharmaceutics13020292
Abstract: Epidermal growth factor receptor (EGFR) is overexpressed in many malignancies. EGFR-targeted therapy extends survival of patients with disseminated cancers. Radionuclide molecular imaging of EGFR expression would make EGFR-directed treatment more personalized and therefore more efficient.… read more here.
Keywords: dfo zegfr; zegfr 2377; egfr expression; fold higher ... See more keywords