Biochemical effects of deferasirox and deferasirox-loaded nanomicellesin iron-intoxicated rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119146
Abstract: Deferasirox (DFX) was formulated into oil-in-water microemulsions in the presence of pluronicto improve its oral bioavailability. The size of the DFX-loadedmicroemulsions system measured by dynamic light scattering (DLS) was about 9 nm. The anti-proliferative and anti-lipid… read more here.
Keywords: loaded microemulsions; iron intoxicated; dfx loaded; free dfx ... See more keywords
Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c03816
Abstract: pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively performed in silico, in vitro,… read more here.
Keywords: niosomal dfx; vitro vivo; silico vitro; deferasirox ... See more keywords
Highly sensitive AIEE active fluorescent probe for detection of deferasirox: extensive experimental and theoretical studies
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DOI: 10.1039/d4ra03548h
Abstract: High concentrations of deferasirox (DFX) in living organisms cause hepatic, gastric and renal malfunctions. Therefore, it is significant to establish an accurate and efficient approach for the detection of deferasirox (DFX) to protect public health.… read more here.
Keywords: detection deferasirox; probe mpt; probe; dfx ... See more keywords
Add-on Milnacipran Boosts Methylphenidate Response in an Adolescent With Attention-Deficit/Hyperactivity Disorder With Comorbid Anxiety and Enuresis.
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000884
Abstract: generally well controlled after switching from DFXDT to DFX-G. This finding indicates that the DFX formulation can be switched without a loss of efficacy if appropriate doses are used. The requirement for drug administration before… read more here.
Keywords: boosts methylphenidate; response adolescent; milnacipran boosts; methylphenidate response ... See more keywords
Treatment With Topical Deferoxamine Improves Cutaneous Vascularity and Tissue Pliability in an Irradiated Animal Model of Tissue Expander–Based Breast Reconstruction
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Plastic Surgery"
DOI: 10.1097/sap.0000000000001655
Abstract: Purpose Postmastectomy radiation therapy is an important component of the multimodality approach to later-stage breast cancers. Unfortunately, despite its proven survival benefits, postmastectomy radiation therapy is deleterious to the skin and soft tissue, causing increased… read more here.
Keywords: treatment; dfx; tissue; group ... See more keywords
Deferasirox, an iron chelator, impacts myeloid differentiation by modulating NF‐kB activity via mitochondrial ROS
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Haematology"
DOI: 10.1111/bjh.19782
Abstract: The iron chelator deferasirox (DFX) is effective in the treatment of iron overload. In certain patients with myelodysplastic syndrome, DFX can also provide a dramatic therapeutic benefit, improving red blood cell production and decreasing transfusion… read more here.
Keywords: differentiation; iron; iron chelator; mitochondrial ros ... See more keywords
Candida albicans enhances iron uptake to maintain fluconazole resistance
Sign Up to like & getrecommendations! Published in 2025 at "Infection and Immunity"
DOI: 10.1128/iai.00002-25
Abstract: ABSTRACT Widespread use of fluconazole has led to the emergence of fluconazole-resistant (FR) Candida spp. causing challenges in clinical treatment. Iron, an essential nutrient, affects the levels of ergosterol (a fluconazole target) in fungal membranes.… read more here.
Keywords: iron uptake; resistance; iron; candida ... See more keywords
Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety Comparison of Deferasirox Formulations for Treatment Tailoring
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DOI: 10.1182/blood-2019-122030
Abstract: Introduction: The majority of published data about Deferasirox (DFX) are obtained on the dispersible formulation (DFX DT). A film-coated formulation (DFX FCT) with higher bioavailability is now approved and used in most countries, in tablets… read more here.
Keywords: dfx fct; treatment; safety; formulation ... See more keywords
Repurposing of the Iron Chelator Deferasirox to Overcome Venetoclax Resistance in Mantle Cell Lymphoma Via Downregulation of MCL1
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202600
Abstract: Mantle cell lymphoma (MCL) is a difficult to treat B-cell malignancy characterized by cyclin D1 (CD1) overexpression and deregulated AKT, NFκB, MAPK, B-cell receptor and BCL2 pathways. Breakthrough treatments such as BTK inhibitors present clinical… read more here.
Keywords: resistance; mcl1; jeko; cell ... See more keywords
Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11081507
Abstract: Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the… read more here.
Keywords: supplementation; ilex paraguariensis; paraguariensis; dfx ... See more keywords
Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15165709
Abstract: New antibiotics are seen as ‘drugs of last resort’ against virulent bacteria. However, development of resistance towards new antibiotics with time is a universal fact. Delafloxacin (DFX) is a new fluoroquinolone antibiotic that differs from… read more here.
Keywords: nano; fluoroquinolone antibiotic; dfx aunps; dfx ... See more keywords