Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Medical Oncology"
DOI: 10.1007/s12032-019-1327-4
Abstract: Diffuse type gastric cancer (DGC), a pathological subtype, is one of the most common malignant solid tumors, and mortality of this tumor is not negligible, especially in early-onset cancer patients. In fact, affirmative personalized treatments… read more here.
Keywords: medicine; diffuse type; dgc; cancer ... See more keywords
Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02270-5
Abstract: Diffuse-type gastric cancer (DGC) is a highly invasive subtype of gastric adenocarcinoma that frequently exhibits scattered peritoneal metastasis. Previous studies have shown that the genes of receptor tyrosine kinases (RTKs), such as fibroblast growth factor… read more here.
Keywords: dgc; type gastric; fibroblast growth; gastric cancer ... See more keywords
Outcomes of Endoscopic Surveillance in Individuals With Genetic Predisposition to Hereditary Diffuse Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.03.047
Abstract: BACKGROUND & AIMS Pathogenic germline variants in CDH1 are associated with risk for diffuse gastric cancer (DGC) and lobular breast cancer. The reported high incidence of DGC and limited sensitivity of endoscopy in detection have… read more here.
Keywords: variants cdh1; gastric cancer; family; diffuse gastric ... See more keywords
SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling
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DOI: 10.3390/cancers13174309
Abstract: Simple Summary Diffuse-type gastric carcinoma (DGC) is characterized by rapid infiltrative growth associated with massive stroma and frequent peritoneal dissemination, which leads to poor patient outcomes. In this study, we found that the oncogenic tyrosine… read more here.
Keywords: gastric carcinoma; tyrosine; dgc; receptor ... See more keywords
Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma
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DOI: 10.3892/ol.2021.13083
Abstract: Diffuse gastric carcinoma (DGC) is characterized by poorly cohesive cells, highly invasive growth patterns, poor prognosis and resistance to the majority of available systemic therapeutic strategies. It has been previously reported that the Wnt/β-catenin signaling… read more here.
Keywords: sfrp3; dvl3; dgc; dvl2 ... See more keywords
Methylation and Polymorphism in CDH1 Gene Promoter Among Patients with Diffuse Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Preventive Medicine"
DOI: 10.4103/ijpvm.ijpvm_288_20
Abstract: Background: The promoter methylation and single nucleotide polymorphisms (SNPs) affect the transcription activity of cancer-related genes in several cancers including diffuse gastric cancer (DGC). Here we aimed to evaluate the promoter methylation status and the… read more here.
Keywords: promoter; methylation; dgc; cdh1 gene ... See more keywords