Predominant contribution of DGKζ over DGKα in the control of PKC/PDK‐1‐regulated functions in T cells
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.7
Abstract: Diacylglycerol kinase (DGK)‐mediated consumption of the diacylglycerol (DAG) generated in response to antigen recognition is an important mechanism to limit T‐cell function. Targeting DGK activity presents new opportunities for therapeutic manipulation of the immune response,… read more here.
Keywords: dgk dgk; dgk; contribution; kinase ... See more keywords
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aax3332
Abstract: Allergic inflammation and airway hyperresponsiveness in asthma are independently exacerbated by DGK activity. DGKζ activates airways Asthma is characterized by both T cell–mediated inflammation and airway smooth muscle cell hyperreactivity. In T cells, activation stimulates… read more here.
Keywords: dgk; inflammation; airway inflammation; inflammation airway ... See more keywords
107 Metabolic reprogramming to enhance the efficacy of mtor inhibition in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2017-000663.107
Abstract: Purpose of study PI3K/mTOR pathway is mutated in 10%–20% of colorectal cancer (CRC) specimens and has been associated with poor survival. In this study, we found diacylglycerol kinase (DGK), involved in lipid signalling, to be… read more here.
Keywords: dgk; mtor inhibition; tak 228; inhibition ... See more keywords
Abstract 973: The mitochondrial deoxyguanosine kinase regulates lung adenocarcinoma cancer stem-like cells through AMPK/YAP1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-973
Abstract: Metastasis involves the dissemination of tumor cells from primary site to distant organs, and the colonization of disseminated cancer cells to establish distant metastases. Some of the disseminated cancer stem-like cells (CSC) are able to… read more here.
Keywords: dgk; cancer; yap1 signaling; tumor ... See more keywords
DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m079723
Abstract: Diacylglycerol kinases (DGKs) regulate the balance between diacylglycerol (DAG) and phosphatidic acid. DGKζ is highly abundant in skeletal muscle and induces fiber hypertrophy. We hypothesized that DGKζ influences functional and metabolic adaptations in skeletal muscle… read more here.
Keywords: skeletal muscle; insulin; dgk; dgk deficiency ... See more keywords
Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032113
Abstract: Introduction Activation of T cell receptor (TCR) signaling is critical for clonal expansion of CD8+ T cells. However, the effects of augmenting TCR signaling during chronic antigen exposure is less understood. Here, we investigated the… read more here.
Keywords: cell; infection; cd8; erk ... See more keywords
Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.855673
Abstract: Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase θ (DGKθ), which produces phosphatidic… read more here.
Keywords: kinase activity; dgk interactors; activity; dgk kinase ... See more keywords
Diacylglycerol Kinase ε in Adipose Tissues: A Crosstalk Between Signal Transduction and Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.815085
Abstract: Diacylglycerol (DG) is unique in lipid metabolism because it serves not only as an intermediate product for triglyceride synthesis, but also as a signaling molecule that activates proteins containing DG-responsive elements, such as protein kinase… read more here.
Keywords: dgk; energy metabolism; kinase; metabolism ... See more keywords
DGKα, Bridging Membrane Shape Changes with Specific Molecular Species of DAG/PA: Implications in Cancer and Immunosurveillance
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215259
Abstract: Simple Summary DGKα is being considered as a target in immunotherapy. An advantage of targeting this enzyme is that it potentially has a dual role, i.e., it would both decrease the proliferation of cancer cells… read more here.
Keywords: membrane shape; role; biology; cancer ... See more keywords