Inhibition of diacylglycerol kinase alpha to augment antitumor effector T cells in tumor-bearing host.
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DOI: 10.1200/jco.2019.37.4_suppl.293
Abstract: 293 Background: Diacylglycerol kinases (DGKs), lipid kinases transforming diacylglycerol to phosphatidic acid, play important roles in intracellular signal transduction. Diacylglycerol kinase alpha (DGKa), an isozyme of DGKs, is well-known to promote proliferation of cancer cells… read more here.
Keywords: tumor bearing; cd8 cells; tumor; dgka ... See more keywords