Retrospective analysis on R‐DHAP/OX and ASCT as salvage treatment for relapsed/refractory high‐risk follicular lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_119
Abstract: The outcome of patients with follicular lymphoma (FL) experiencing disease progression within the first two years from first-line chemo-immunotherapy is poor and optimal subsequent management is uncertain. The combination of rituximab, dexamethasone, high-dose cytarabine, and… read more here.
Keywords: dhap; line; first line; chemo immunotherapy ... See more keywords
Degradable hyperbranched polymer with fouling resistance for antifouling coatings
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Organic Coatings"
DOI: 10.1016/j.porgcoat.2021.106141
Abstract: Abstract The controlled release of antifoulant is critical in marine antifouling, which is profoundly influenced by the compatibility between polymer resin and antifoulant. Conjugation of polymers with active molecules provides a promising strategy to solve… read more here.
Keywords: coatings degradable; dhap; antifouling coatings; hyperbranched polymer ... See more keywords
Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01103
Abstract: Human liver glycerol 3-phosphate dehydrogenase ( hlGPDH) catalyzes the reduction of dihydroxyacetone phosphate (DHAP) to form glycerol 3-phosphate, using the binding energy associated with the nonreacting phosphodianion of the substrate to properly orient the enzyme-substrate… read more here.
Keywords: dhap; transition; kcal mol; glycerol phosphate ... See more keywords
Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00371-9
Abstract: Even though the mTOR complex has been known for decades as a nutrient sensor, being thus in focus for drug targeting in metabolic disease and cancer metabolism, it has remained puzzling how it is able… read more here.
Keywords: dhap; metabolism; mtorc1 activation; mtorc1 ... See more keywords
Physiological effects of autotoxicity due to DHAP stress on Picea schrenkiana regeneration
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DOI: 10.1371/journal.pone.0177047
Abstract: Picea Schrenkiana as one of the most important zonal vegetation was an endemic species in Middle Asia. Natural regeneration of P. Schrenkiana is a long existing problem troubling scientists. The autotoxicity of 3,4-dihydroxy-acetophenone (DHAP) was… read more here.
Keywords: autotoxicity; dhap; regeneration; picea schrenkiana ... See more keywords
Ibrutinib Associated with Rituximab-Platinum Salt-Based Immunochemotherapy in B-Cell Lymphomas: Results of a Phase 1b-II Study of the LYSA Group
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071761
Abstract: Simple Summary Patients with relapsing/refractory B-cell lymphoma who respond to a platinum salt-based salvage regimen can be cured after therapy intensification followed by autologous stem cell transplantation. The Bruton tyrosine kinase inhibitor ibrutinib, given alone… read more here.
Keywords: cell; ibrutinib; salt based; platinum salt ... See more keywords
Synthesis, oral bioavailability evaluation and antiplatelet aggregation activity of three derivatives of 3,4‑dihydroxyacetophenone.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2020.4469
Abstract: 3,4‑Dihydroxyacetophenone (DHAP) exerts therapeutic effects on cardiovascular disease and pulmonary heart disease. However, it is not utilized as a clinical drug due to its rapid metabolism, short‑acting effect and low oral bioavailability. In the present… read more here.
Keywords: aggregation activity; oral bioavailability; dhap; bioavailability ... See more keywords