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   Articles with "dhca" as a keyword



Dehydrodiconiferyl alcohol promotes BMP-2-induced osteoblastogenesis through its agonistic effects on estrogen receptor.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.12.079

Abstract: Estrogen deficiency results in an imbalance between the levels of bone-resorping osteoclasts and bone-forming osteoblasts, eventually leading to overall bone loss. Dehydrodiconiferyl alcohol (DHCA), a lignan compound originally isolated from Cucurbita moschata, has been shown… read more here.

Keywords: dhca; induced osteoblastogenesis; bmp induced; osteoblastogenesis ... See more keywords

179: METABOLOMIC FINGERPRINTING IN A PIGLET MODEL OF INFANT CARDIAC SURGERY-INDUCED ACUTE KIDNEY INJURY

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recommendations! Published in 2020 at "Critical Care Medicine"

DOI: 10.1097/01.ccm.0000619076.92191.53

Abstract: Introduction/Hypothesis: The pathologic tissue and urine metabolic fingerprints of cardiac surgery-induced acute kidney injury (AKI) have not been well defined. In this study, we utilized a porcine model of infant cardiopulmonary bypass (CPB) with deep… read more here.

Keywords: surgery induced; tissue; dhca; cardiac surgery ... See more keywords
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Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming.

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recommendations! Published in 2019 at "Artificial organs"

DOI: 10.1111/aor.13407

Abstract: Brain injury associated with deep hypothermic circulatory arrest (DHCA) has been recognized in patients with congenital heart diseases and those undergoing aortic arch surgeries. However, the preclinical investigation of long-term cerebral injury and recovery mechanisms… read more here.

Keywords: recovery; long term; dhca; model ... See more keywords

The dynamic changes in autophagy activity and its role in lung injury after deep hypothermic circulatory arrest

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recommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.17165

Abstract: Deep hypothermic circulatory arrest (DHCA) can cause acute lung injury (ALI), and its pathogenesis mimics ischaemia/reperfusion (I/R) injury. Autophagy is also involved in lung I/R injury. The present study aimed to elucidate whether DHCA induces… read more here.

Keywords: dhca; lung injury; role; injury ... See more keywords

Effects of different doses of ulinastatin on organ protection of deep hypothermic circulatory arrest in rats

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recommendations! Published in 2025 at "Journal of Cardiothoracic Surgery"

DOI: 10.1186/s13019-025-03379-w

Abstract: Deep hypothermic circulatory arrest (DHCA) can cause systemic inflammatory response (SIR) and ischemia-reperfusion (I/R) injury, potentially exacerbating organ failure. Ulinastatin (UTI) is a frequently employed anti-inflammatory medication in clinical practice, but different timing and dosage… read more here.

Keywords: uti uti; 001 001; dhca; group ... See more keywords

Transcriptome profiling and weighted gene co-expression network analysis reveal changes of hub genes and molecular pathways in rat lungs following deep hypothermic circulatory arrest

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0328887

Abstract: Background The incidence of acute lung injury (ALI) following aortic dissection repair surgery that involves deep hypothermic circulatory arrest (DHCA) is notably high. We analyzed hub genes and signaling pathways in rat lung tissues post-DHCA… read more here.

Keywords: lung; gene expression; dhca; gene ... See more keywords

Cannabinoid Receptor Agonist WIN55, 212-2 Attenuates Injury in the Hippocampus of Rats after Deep Hypothermic Circulatory Arrest

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recommendations! Published in 2023 at "Brain Sciences"

DOI: 10.3390/brainsci13030525

Abstract: Objectives: Postoperative neurological deficits remain a challenge in cardiac surgery employing deep hypothermic circulatory arrest (DHCA). This study aimed to investigate the effect of WIN55, 212-2, a cannabinoid agonist, on brain injury in a rat… read more here.

Keywords: circulatory arrest; win55 212; dhca; deep hypothermic ... See more keywords