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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.011
Abstract: The enzyme Δ24-dehydrocholesterol reductase (DHCR24) catalyzes the reduction of the Δ24-double bond in the side chain of cholesterol precursors. Recent biochemical investigations fuel the hope that inhibition of DHCR24, resulting in an accumulation of desmosterol,…
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Keywords:
new chemotype;
selective potent;
dehydrocholesterol reductase;
dhcr24 ... See more keywords
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Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0991-6
Abstract: BackgroundDHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer’s disease.MethodsHere,…
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Keywords:
induced neuronal;
overexpression;
neuronal death;
inflammation ... See more keywords
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Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.901408
Abstract: Background Apolipoprotein (apo) A-IV, the third most abundant apolipoprotein in human high density lipoproteins (HDLs), inhibits intestinal and systemic inflammation. This study asks if apoA-IV also inhibits acute vascular inflammation. Methods Inflammation was induced in…
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Keywords:
inflammation;
vascular inflammation;
tnf;
vcam icam ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24020933
Abstract: Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of the…
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Keywords:
mouse adrenal;
gland;
cholesterol synthesis;
adrenal gland ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062643
Abstract: Hyperlipidemia is a risk factor for the development of fatty liver and cardiovascular diseases such as atherosclerosis and coronary heart disease, and hence, cholesterol-lowering drugs are considered important and effective in preventing cardiovascular diseases. Thus,…
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Keywords:
hyperlipidemia;
cholesterol lowering;
activity;
irbesartan ... See more keywords
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Published in 2022 at "Investigative and Clinical Urology"
DOI: 10.4111/icu.20220153
Abstract: Purpose This research concentrated on the biological effects and special mechanism of circ_0003221 in bladder cancer (BLCA). Materials and Methods The level quantification by reverse transcription-quantitative polymerase chain reaction was administrated for circ_0003221, microRNA-892b (miR-892b)…
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Keywords:
mir 892b;
bladder cancer;
circ 0003221;
dhcr24 ... See more keywords