Ergosterol increases 7-dehydrocholesterol, a cholesterol precursor, and decreases cholesterol in human HepG2 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Lipids"
DOI: 10.1002/lipd.12357
Abstract: Current treatment approaches for hyperlipidemia rely mainly on reducing the cholesterol level by inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which is involved in the presqualene pathway of cholesterol biosynthesis. Finding a compound that instead targets the postsqualene… read more here.
Keywords: human hepg2; dehydrocholesterol; dhcr7; cholesterol ... See more keywords
SU61 ASSESSING BEHAVIOR AND ANXIETY IN THE DHCR7Δ3-5/T93M MOUSE MODEL OF SMITH-LEMLI-OPITZ SYNDROME
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DOI: 10.1016/j.euroneuro.2017.08.250
Abstract: Background Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive inborn error of cholesterol synthesis caused by mutation of the 7-dehydrocholesterol reductase (DHCR7) gene. This results in abnormal sterol levels, increased 7-dehydrocholesterol and typically decreased cholesterol. Although… read more here.
Keywords: test; dhcr7t93m mice; model; mice ... See more keywords
Novel DHCR7 mutation in a case of Smith–Lemli–Opitz syndrome showing 46,XY disorder of sex development
Sign Up to like & getrecommendations! Published in 2017 at "Human Genome Variation"
DOI: 10.1038/hgv.2017.15
Abstract: Smith–Lemli–Opitz syndrome is an autosomal recessive disease caused by mutations in 7-dehydrocholesterol reductase (DHCR7), which is rarely observed in Japan. We report a Japanese case with 46,XY disorder of sex development and Y-shaped 2–3 toe… read more here.
Keywords: lemli opitz; opitz syndrome; sex development; smith lemli ... See more keywords