Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT‐1 via σ1 receptor‐mediated PKC activation in the hippocampal dentate gyrus of rats
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DOI: 10.1002/glia.23175
Abstract: Neurosteroid dehydroepiandrosterone (DHEA) has been reported to exert a potent neuroprotective effect against glutamate‐induced excitotoxicity. However, the underlying mechanism remains to be elucidated. One of the possible mechanisms may be an involvement of astrocytic glutamate… read more here.
Keywords: glt; dentate gyrus; activity; neurosteroid dehydroepiandrosterone ... See more keywords
The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25991
Abstract: The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity… read more here.
Keywords: development; impact pubertal; pubertal dhea; dhea ... See more keywords
Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance)
Sign Up to like & getrecommendations! Published in 2017 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-017-3960-9
Abstract: BackgroundDehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history.MethodsPostmenopausal women, diagnosed with breast… read more here.
Keywords: effects vaginal; dhea; day dhea; cytology ... See more keywords
DHEA-pretreatment attenuates oxidative stress in kidney-cortex and liver of diabetic rabbits and delays development of the disease.
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DOI: 10.1016/j.biochi.2021.03.010
Abstract: In view of reported discrepancies concerning antioxidant activity of dehydroepiandrosterone (DHEA), a widely used dietary supplement, the current investigation was undertaken to evaluate the antioxidant properties of DHEA in both kidney-cortex and liver of alloxan… read more here.
Keywords: diabetic rabbits; dhea; cortex liver; kidney cortex ... See more keywords
Maintaining physiologic testosterone levels during combined oral contraceptives by adding dehydroepiandrosterone: II. Effects on sexual function. A phase II randomized, double-blind, placebo-controlled study.
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DOI: 10.1016/j.contraception.2018.02.014
Abstract: OBJECTIVE The objective was to evaluate the effect of combined oral contraceptives (OCs) on sexual function, either alone or together with dehydroepiandrosterone (DHEA). STUDY DESIGN An exploratory randomized, double-blind, placebo-controlled, comparative, crossover study was conducted… read more here.
Keywords: sexual function; study; testosterone; placebo ... See more keywords
Impact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A dose-response meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2020 at "Complementary therapies in medicine"
DOI: 10.1016/j.ctim.2020.102620
Abstract: BACKGROUND Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA… read more here.
Keywords: elderly women; dhea supplementation; dhea; testosterone concentrations ... See more keywords
Assessing the effect of MitoQ10 and Vitamin D3 on ovarian oxidative stress, steroidogenesis and histomorphology in DHEA induced PCOS mouse model
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DOI: 10.1016/j.heliyon.2020.e04279
Abstract: Polycystic ovary syndrome (PCOS) continues to be one of the most complex reproductive and endocrine disorder among women of reproductive age. Recent reports have identified close interaction of Vitamin D deficiency and oxidative stress (OS)… read more here.
Keywords: mitoq10; group; mitoq10 vitamin; vitamin ... See more keywords
Oral dehydroepiandrosterone might prevent frequent tears in atrophic skin: A case report
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DOI: 10.1016/j.jdcr.2017.09.019
Abstract: INTRODUCTION Large superficial tears frequently develop during minor trauma to the fragile skin of older men and women. These tears are more common in chronically ill or malnourished patients, can develop during attempted assisted transfer… read more here.
Keywords: dehydroepiandrosterone might; prevent frequent; case; might prevent ... See more keywords
iTRAQ-based quantitative proteomic analysis of Colletotrichum lini reveals ethanol induced mechanism for enhancing dihydroxylation efficiency of DHEA.
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DOI: 10.1016/j.jprot.2020.103851
Abstract: Colletotrichum lini is used as an industrial stain for the dihydroxylation of steroid compound dehydroepiandrosterone (DHEA) to biosynthesize 3β,7α,15α-trihydroxy-5-androstene-17-one (7α,15α-diOH-DHEA), a key intermediate of the most popular oral contraceptive "Yasmin". This work aimed to enhance… read more here.
Keywords: mechanism; lini; dihydroxylation; ethanol induction ... See more keywords
The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway.
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DOI: 10.1016/j.lfs.2021.119456
Abstract: BACKGROUND In recent years, female infertility from Polycystic Ovary Syndrome (PCOS) has gained scientific interest. PCOS alters the metabolic and endocrine functioning in females. The elevation in androgens can damage the androgen receptors present on… read more here.
Keywords: tgf pathway; polycystic ovary; ovary syndrome; dhea ... See more keywords
Cortisol, DHEA and DHEA-S during exposure therapy in patients with obsessive-compulsive disorder – secretion patterns and prediction of treatment response
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DOI: 10.1016/j.psychres.2020.113288
Abstract: The cortisol response in patients with obsessive-compulsive disorder (OCD) during exposure with response prevention (ERP), a stressful but very effective psychotherapeutic treatment, has shown contradictory findings in three prior studies with low sample sizes. In… read more here.
Keywords: cortisol; response; obsessive compulsive; treatment ... See more keywords