Development of an Acrylamide-Based Inhibitor of Protein S-Acylation.
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DOI: 10.1021/acschembio.1c00405
Abstract: Protein S-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, the installation of the lipid onto target proteins is catalyzed by a family of 23… read more here.
Keywords: protein acylation; dhhc family; inhibitor; acylation ... See more keywords
A High-Throughput Fluorescent Turn-On Assay for Inhibitors of DHHC Family Proteins
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DOI: 10.1021/acschembio.2c00193
Abstract: As the “writer” enzymes of protein S-acylation, a dynamic and functionally significant post-translational modification (PTM), DHHC family proteins have emerged in the past decade as both key modulators of cellular homeostasis and as drivers of… read more here.
Keywords: family; fluorescent turn; dhhc family; high throughput ... See more keywords