The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting
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DOI: 10.3390/ijms26031359
Abstract: Dihydroorotase (DHOase; EC 3.5.2.3) is a zinc-dependent metalloenzyme that plays a key role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of N-carbamoyl aspartate to dihydroorotate. This reaction is essential for the… read more here.
Keywords: active site; mode; loop binding; dhoase ... See more keywords