DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of immunology"
DOI: 10.1093/jimmun/vkaf023
Abstract: Acute graft-versus-host disease (GVHD) is a donor T cell driven complication and the leading cause of non-relapse mortality in patients receiving an allogeneic hematopoietic cell transplantation (allo-HCT). Allogeneic donor T cells eradicate residual leukemia and… read more here.
Keywords: host; dhodh inhibition; leukemia; graft ... See more keywords
Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.730342
Abstract: Background and Objectives Inhibition of de novo pyrimidine synthesis in proliferating T and B lymphocytes by teriflunomide, a pharmacological inhibitor of dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy to treat patients… read more here.
Keywords: cd8; treatment; dhodh inhibition; patients rrms ... See more keywords