Pregnane neurosteroids exert opposite effects on GABA and glycine‐induced chloride current in isolated rat neurons
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23449
Abstract: The ability of endogenous neurosteroids (NSs) with pregnane skeleton modified at positions C‐3 and C‐5 to modulate the functional activity of inhibitory glycine receptors (GlyR) and ionotropic ɣ‐aminobutyric acid receptors (GABAAR) was estimated. The glycine… read more here.
Keywords: peak amplitude; glycine; dhp; isolated rat ... See more keywords
Speciation of potential anti-diabetic vanadium complexes in real serum samples.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.04.023
Abstract: In this work the speciation in real serum samples of five VIVO complexes with potential application in the therapy of diabetes was studied through EPR spectroscopy as a function of V concentration (45.4, 90.9 and… read more here.
Keywords: dhp; serum samples; serum; real serum ... See more keywords
Enhanced solid-state photoluminescence and fluorescence spectral behaviors for an ESIPT molecule: An experimental and theoretical investigation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114176
Abstract: Abstract 3-Dimethylamino-1-(2-hydroxy-phenyl)-propenone (DHP) molecule with excited-state intramolecular proton transfer (ESIPT), was good candidate as active organic laser dyes. In this work, the enhanced solid-state photoluminescence and the structure-property relationship for photophysical properties are investigated by… read more here.
Keywords: state; dhp; solid state; isomer ... See more keywords
1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-cysteine Conjugates - Metabolic Formation and Binding to Cellular DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00143
Abstract: 1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP) is a potential proximate carcinogenic metabolite of pyrrolizidine alkaloids. In the present study, we determined that reaction of 1-CHO-DHP with cysteine generated four identified products. By mass and 1H NMR spectral analysis, these… read more here.
Keywords: dhp; cho dhp; formyl hydroxy; dihydro pyrrolizine ... See more keywords
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00321
Abstract: 1,2-Unsaturated pyrrolizidine alkaloids (PAs) are carcinogenic phytochemicals. We previously determined that carcinogenic PAs and PA N-oxides commonly form a set of four (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-DNA adducts, namely, DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4. This set of DHP-DNA… read more here.
Keywords: metabolism; dna; dhp; containing plant ... See more keywords
1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00038
Abstract: Pyrrolizidine alkaloids (PAs) are phytochemicals present in more than 6000 plant species worldwide; about half of the PAs are hepatotoxic, genotoxic, and carcinogenic. Because of their wide exposure and carcinogenicity, the International Programme on Chemical… read more here.
Keywords: dhp; dna adducts; cho dhp; dhp dna ... See more keywords
Protective effects of Dendrobium huoshanense polysaccharide on D-gal induced PC12 cells and aging mice, in vitro and in vivo studies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14496
Abstract: Dendrobium huoshanense C. Z. Tang et S. J. Cheng polysaccharide (DHP) is the essential active ingredient of D.huoshanense and has high medicinal value. A high dose of D-galactose (D-gal) is commonly utilized in the aging… read more here.
Keywords: vitro; vivo; dhp; pc12 cells ... See more keywords
Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0168702
Abstract: Background Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based combination therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission in areas threatened by artemisinin resistance. To date, no randomized… read more here.
Keywords: dhp; transmission; falciparum; dose primaquine ... See more keywords
A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of basic and clinical physiology and pharmacology"
DOI: 10.1515/jbcpp-2020-0162
Abstract: OBJECTIVES The use of standard antimalarial drugs, such as dihydroartemisinin-piperaquine (DHP) for the treatment of malaria during pregnancy is limited due to the risk of teratogenicity. The alternative is therefore required although few exist. Here we show… read more here.
Keywords: dhp; andrographis paniculata; treatment; treatment malaria ... See more keywords
The divergent pH dependence of substrate turnover in dehaloperoxidases A and B.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inorganic biochemistry"
DOI: 10.2139/ssrn.4141044
Abstract: The pH-dependent peroxidase activity in both dehaloperoxidases A and B was studied by a kinetic assay, stopped flow spectroscopy, resonance Raman spectroscopy, and high-performance liquid chromatography at pH 5.0, 6.0, and 7.0. At pH 7.0, both isozymes… read more here.
Keywords: divergent dependence; oxidation; spectroscopy; dhp ... See more keywords
Synthesis and Antibacterial Properties of Oligomeric Dehydrogenation Polymer from Lignin Precursors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051466
Abstract: The lignin precursors of coniferin and syringin were synthesised, and guaiacyl-type and guaiacyl-syringyl-type oligomeric lignin dehydrogenation polymers (DHP and DHP-GS) were prepared with the bulk method. The carbon-13 nuclear magnetic resonance spectroscopy showed that both… read more here.
Keywords: lignin; antibacterial activity; dhp; lignin precursors ... See more keywords