Differential mechanisms of tolerance induced by NMDA and 3,5‐dihydroxyphenylglycine (DHPG) preconditioning
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DOI: 10.1111/jnc.15033
Abstract: We investigated the molecular events triggered by NMDA and 3,5‐dihydroxyphenylglycine (DHPG) preconditioning, that lead to neuroprotection against excitotoxic insults (AMPA or oxygen and glucose deprivation) in rat organotypic hippocampal slices, with particular attention on glutamate… read more here.
Keywords: ampa; tolerance; nmda dihydroxyphenylglycine; dhpg ... See more keywords
The role of ectopic P granules protein 5 homolog (EPG5) in DHPG‐induced pain sensitization in mice
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DOI: 10.1111/jnc.15779
Abstract: Nociplastic pain is a severe health problem, while its mechanisms are still unclear. (R, S)‐3,5‐Dihydroxyphenylglycine (DHPG) is a group I metabotropic glutamate receptor (mGluR) agonist that can cause central sensitization, which plays a role in… read more here.
Keywords: role; sensitization; ectopic granules; mice ... See more keywords
Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method development for a translational research study
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DOI: 10.1186/s13104-018-3352-3
Abstract: ObjectiveNorepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is important to measure its principal metabolite, 3,4-dihydroxyphenylglycol (DHPG), concurrently. Our aim was… read more here.
Keywords: research; method; dhpg; research study ... See more keywords