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   Articles with "dhx15" as a keyword



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DHX15 is required to control RNA virus-induced intestinal inflammation

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109205

Abstract: SUMMARY RNA helicases play critical roles in various biological processes, including serving as viral RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 (DHX15) is essential for type I interferon… read more here.

Keywords: dhx15; intestinal inflammation; ifn; rna ... See more keywords
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Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.

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recommendations! Published in 2019 at "Human molecular genetics"

DOI: 10.1093/hmg/ddz261

Abstract: DHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ~ 6% of acute myeloid leukemia (AML)… read more here.

Keywords: dhx15; tp53 mdm2; splicing factor; expression ... See more keywords
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The DEAD-box RNA helicase Dhx15 controls glycolysis and arbovirus replication in Aedes aegypti mosquito cells

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recommendations! Published in 2022 at "PLOS Pathogens"

DOI: 10.1371/journal.ppat.1010694

Abstract: Aedes aegypti mosquitoes are responsible for the transmission of arthropod-borne (arbo)viruses including dengue and chikungunya virus (CHIKV), but in contrast to human hosts, arbovirus infected mosquitoes are able to efficiently control virus replication to sub-pathological… read more here.

Keywords: aedes aegypti; replication; dhx15; arbovirus replication ... See more keywords
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DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.20288

Abstract: The role of DHX15, a newly identified DEAH-box RNA helicase, in leukemogenesis remains elusive. Here, we identified a recurrent mutation in DHX15 (NM_001358:c.664C>G: p.(R222G)) in one familial AML patient and 4/240 sporadic AML patients. Additionally,… read more here.

Keywords: dhx15; apoptosis; cell apoptosis; aml ... See more keywords