Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Sciences"
DOI: 10.1007/s10072-017-3166-4
Abstract: Diabetes mellitus is associated with dementia, but whether diabetes is associated with Alzheimer’s disease remains controversial. Alzheimer’s disease is characterized by amyloid beta aggregation. We hypothesized that genes, involved in amyloid beta degradation, may be… read more here.
Keywords: matrix metalloproteinase; alzheimer disease; amyloid beta; disease ... See more keywords
Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hypertension"
DOI: 10.1093/ajh/hpy046
Abstract: BACKGROUND Hypertension affects 33% of Americans while type 2 diabetes and Alzheimer's disease (AD) affect 10% of Americans, respectively. Ryanodine receptor 3 gene (RYR3) codes for the RYR which functions to release stored endoplasmic reticulum… read more here.
Keywords: risk; hypertension diabetes; disease; diabetes alzheimer ... See more keywords
Oxidative toxicity in diabetes and Alzheimer’s disease: mechanisms behind ROS/ RNS generation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-017-0379-z
Abstract: Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer’s disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, RNA, protein and lipid products… read more here.
Keywords: alzheimer disease; toxicity diabetes; disease; diabetes alzheimer ... See more keywords
Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13010183
Abstract: Type 2 diabetes (T2D) and Alzheimer’s diseases (AD) represent major health issues that have reached alarming levels in the last decades. Although growing evidence demonstrates that AD is a significant comorbidity of T2D, and there… read more here.
Keywords: alzheimer disease; type diabetes; emerging role; disease emerging ... See more keywords
A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911562
Abstract: Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is… read more here.
Keywords: pathophysiological intersection; disease; alzheimer disease; intersection diabetes ... See more keywords
Efficient one-pot synthesis of arylated pyrazole-fused pyran analogs: as leads to treating diabetes and Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0103
Abstract: Background: To discover novel lead molecules against diabetes, Alzheimer's disease and oxidative stress, a library of arylated pyrazole-fused pyran derivatives, 1-20, were synthesized in a one-pot reaction. Materials & methods:1H-NMR spectroscopic and electron ionization mass… read more here.
Keywords: pyrazole fused; alzheimer disease; fused pyran; arylated pyrazole ... See more keywords