Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aam9563
Abstract: Reducing IL-2 signaling in T cells results in accelerated diabetes in mice due to defective regulatory T cell function. IL-2 signaling and autoimmunity Regulatory T cells (Tregs) suppress autoreactive effector T cells to prevent the… read more here.
Keywords: homeostasis; regulatory cell; diabetes nod; effector ... See more keywords
Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice
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DOI: 10.2337/db20-0896
Abstract: Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic β-cells by autoreactive effector T cells (Teffs), causing spontaneous autoimmune diabetes in NOD mice. We investigated the contribution to diabetes of the T-cell receptor… read more here.
Keywords: regulatory cell; activated memory; diabetes nod; mice ... See more keywords
Sustained high glucose intake accelerates type 1 diabetes in NOD mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1037822
Abstract: Introduction Epidemiological studies have suggested that dietary factors, especially high consumption of high glycaemic index carbohydrates and sugars, may trigger or exacerbate the progression of type 1 diabetes. We aimed to provide experimental evidence to… read more here.
Keywords: nod mice; sustained high; high glucose; type diabetes ... See more keywords