Epigenetics Variation and Pathogenesis in Diabetes
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DOI: 10.1007/s11892-018-1091-4
Abstract: Purpose of ReviewGreat strides have recently been made in elucidating the role of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are focusing on other factors that may contribute to the pathogenesis of diabetes, such… read more here.
Keywords: pathogenesis diabetes; diabetes pathogenesis; pathogenesis; epigenetics variation ... See more keywords
New mediators in diabetes pathogenesis: exosomes and metabolites.
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DOI: 10.1111/jdi.13654
Abstract: Type 2 diabetes is a systemic disorder characterized by metabolic impairment in multiple organs1 . Various factors trigger insulin resistance in muscle, liver and adipose tissue resulting in increased insulin demand and de-repression of hepatic… read more here.
Keywords: mediators diabetes; diabetes pathogenesis; new mediators; exosomes metabolites ... See more keywords
β-Cell Autophagy in Diabetes Pathogenesis.
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DOI: 10.1210/en.2017-03273
Abstract: Nearly 100 years have passed since Frederick Banting and Charles Best first discovered and purified insulin. Their discovery and subsequent improvements revolutionized the treatment of diabetes, and the field continues to move at an ever-faster… read more here.
Keywords: autophagy diabetes; diabetes pathogenesis; type; cell autophagy ... See more keywords
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
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DOI: 10.1210/endocr/bqac184
Abstract: Abstract The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance and onset of tissue insulin resistance, respectively). However,… read more here.
Keywords: stress; cell; stress response; diabetes pathogenesis ... See more keywords
The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
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DOI: 10.2337/dbi21-0036
Abstract: Recent reports have revived interest in the active role that β-cells may play in type 1 diabetes pathogenesis at different stages of disease. In some studies, investigators suggested an initiating role and proposed that type… read more here.
Keywords: cell; cells may; diabetes pathogenesis; type diabetes ... See more keywords
Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics
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DOI: 10.3389/fendo.2023.1107162
Abstract: Purpose Type 1 diabetes is characterized by elevated blood glucose levels, which negatively impacts multiple organs and tissues throughout the body, and its prevalence is on the rise. Prior reports primarily investigated the serum and… read more here.
Keywords: systematic assessment; diabetic rats; streptozotocin; induced diabetic ... See more keywords
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis
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DOI: 10.3390/metabo12040344
Abstract: The polyamines—putrescine, spermidine, and spermine—are polycationic, low molecular weight amines with cellular functions primarily related to mRNA translation and cell proliferation. Polyamines partly exert their effects via the hypusine pathway, wherein the polyamine spermidine provides… read more here.
Keywords: role polyamines; cells diabetes; translation; hypusine cells ... See more keywords