A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.
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DOI: 10.1002/1873-3468.14561
Abstract: Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK… read more here.
Keywords: young type; diabetes young; maturity onset; onset diabetes ... See more keywords
Diabetic Hepatosclerosis in a Woman with Maturity-Onset Diabetes of the Young Type 3
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DOI: 10.1007/s10620-021-07005-2
Abstract: Diabetic hepatosclerosis (DHS), initially described in 2006, represents a form of diabetic microangiopathy of the liver found in patients with long-standing diabetes mellitus with other microvascular complications [1]. DHS is characterized by hepatic sinusoidal fibrosis… read more here.
Keywords: diabetes young; young type; onset diabetes; maturity onset ... See more keywords
Maturity Onset Diabetes of the Young is Not Necessarily Associated with Autosomal Inheritance: Case Description of a De Novo HFN1A Mutation
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DOI: 10.1007/s13300-019-0633-3
Abstract: Maturity onset diabetes of the young (MODY) accounts for up to 4% of all cases of diabetes in pediatric patients. MODY is usually characterized by autosomal dominant inheritance, impaired insulin secretion, and an average age… read more here.
Keywords: diabetes young; onset diabetes; maturity onset; case ... See more keywords
Using Clinical Indices to Distinguish MODY2 (GCK Mutation) and MODY3 (HNF1A Mutation) from Type 1 Diabetes in a Young Chinese Population
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DOI: 10.1007/s13300-019-0647-x
Abstract: IntroductionAccurate diagnosis of maturity-onset diabetes of the young (MODY) is required in order to select appropriate treatment options and to assess prognosis. The aim of this study was to explore potential clinical indicators that could… read more here.
Keywords: roc derived; mody3; diabetes young; type diabetes ... See more keywords
Ocular surface assessment in maturity-onset diabetes of the young
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DOI: 10.1007/s13410-020-00843-2
Abstract: Aim To examine ocular surface changes in patients with maturity-onset diabetes of young (MODY). Material and methods Fifty patients with MODY who were transferred to Genetic Diagnosis Department of Diskapi Yildirim Beyazit Training and Research… read more here.
Keywords: ocular surface; diabetes young; onset diabetes; maturity onset ... See more keywords
A case of a novel mutation in HNF1β-related maturity-onset diabetes of the young type 5 with diabetic kidney disease complication in a Chinese family.
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DOI: 10.1016/j.jdiacomp.2016.11.011
Abstract: AIMS Precise diagnosis of maturity-onset diabetes of the young (MODY) has proven valuable for understanding mechanism of diabetes and selecting optimal therapy. A proband and her mother with diabetic kidney disease (DKD) were studied to… read more here.
Keywords: diabetes young; onset diabetes; maturity onset; family ... See more keywords
Maturity‐Onset Diabetes of the Young: A Genetic Form of Diabetes in Children☆
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DOI: 10.1016/j.pedn.2016.11.003
Abstract: Clinical Features That Raise Suspicion for MODY. Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are the most commonly recognized disease states characterized by hyperglycemia. However, diabetes compromises many disorders with hyperglycemia as… read more here.
Keywords: diabetes young; young genetic; onset diabetes; maturity onset ... See more keywords
Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China
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DOI: 10.1097/cm9.0000000000002321
Abstract: Abstract Background: Maturity-onset diabetes of the young (MODY) is the most common monogenic diabetes. The aim of this study was to assess the prevalence of MODY in phenotypic type 2 diabetes (T2DM) among Chinese young… read more here.
Keywords: diabetes young; prevalence; mody; maturity onset ... See more keywords
How do I diagnose Maturity Onset Diabetes of the Young (MODY) in my patients?
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DOI: 10.1111/cen.14744
Abstract: Maturity Onset diabetes of the Young (MODY) is a monogenic form of diabetes diagnosed in young individuals that lack the typical features of type 1 and type 2 diabetes. The genetic subtype of MODY determines… read more here.
Keywords: young mody; onset diabetes; diabetes young; maturity onset ... See more keywords
Maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a long‐term diagnosis of type 1 diabetes
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DOI: 10.1111/jdi.13036
Abstract: We report a case of missed diagnosis of maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a previous diagnosis of type 1 diabetes. Maturity‐onset diabetes of the young type 5 cannot be… read more here.
Keywords: young type; diabetes young; onset diabetes; maturity onset ... See more keywords
Pregnancy outcome of Japanese patients with glucokinase–maturity‐onset diabetes of the young
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DOI: 10.1111/jdi.13046
Abstract: Glucokinase–maturity‐onset diabetes of the young (GCK‐MODY; also known as MODY2) is a benign hyperglycemic condition, which generally does not require medical interventions. The only known exception is increased birthweight and related perinatal complications in unaffected… read more here.
Keywords: pregnancy; diabetes young; onset diabetes; maturity onset ... See more keywords