Regulating Macrophage Polarization in High Glucose Microenvironment Using Lithium‐Modified Bioglass‐Hydrogel for Diabetic Bone Regeneration
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DOI: 10.1002/adhm.202200298
Abstract: Diabetes mellitus is a chronic metabolic disease with a proinflammatory microenvironment, causing poor vascularization and bone regeneration. Due to the lack of effective therapy and one‐sided focus on the direct angiogenic properties of biomaterials and… read more here.
Keywords: diabetic bone; microenvironment; hydrogel; bone ... See more keywords
High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration
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DOI: 10.1002/advs.202309491
Abstract: The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired by the discovery that the endoplasmic reticulum (ER) is in a state of excessive… read more here.
Keywords: homeostasis; endoplasmic reticulum; engineered exosomes; bone ... See more keywords
High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration (Adv. Sci. 17/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470099
Abstract: Diabetic Bone Regeneration Inspired by the correlation between endoplasmic reticulum (ER) dysfunction and osteogenesis disorder, Yulan Liu, Mingliang Zhou, Xinquan Jiang, and co‐workers propose in article number 2309491 a novel therapeutic platform comprising a high‐performance… read more here.
Keywords: bone regeneration; endoplasmic reticulum; high performance; diabetic bone ... See more keywords
Functionalized Metal-Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects.
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DOI: 10.1002/smll.202206919
Abstract: The regeneration of diabetic bone defects remains challenging. Hyperglycemia causes inflammation state and excessive reactive oxygen species (ROS) during bone regeneration period. These two effects reinforce one another and create an endless loop that is… read more here.
Keywords: vicious cycle; inflammation; diabetic bone; bone defects ... See more keywords
A Factor-Free Hydrogel with ROS Scavenging and Responsive Degradation for Enhanced Diabetic Bone Healing.
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DOI: 10.1002/smll.202306389
Abstract: In view of the increased levels of reactive oxygen species (ROS) that disturb the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), the repair of diabetic bone defects remains a great challenge. Herein, a… read more here.
Keywords: bone; responsive degradation; ros scavenging; diabetic bone ... See more keywords
Imaging of diabetic bone
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DOI: 10.1007/s12020-017-1278-5
Abstract: Diabetes is an important concern in terms of medical and socioeconomic costs; a high risk for low-trauma fractures has been reported in patients with both type 1 and type 2 diabetes. The mechanism involved in… read more here.
Keywords: risk; bone; fracture risk; imaging diabetic ... See more keywords
The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2016.10.026
Abstract: Skeletal co-morbidities in type 1 diabetes include an increased risk for fracture and delayed fracture healing, which are intertwined with disease duration and the presence of other diabetic complications. As such, chronic hyperglycemia is undoubtedly… read more here.
Keywords: insulin; bone; type diabetes; bone disease ... See more keywords
Directional Biomimetic Scaffold-Mediated Cell Migration and Pathological Microenvironment Regulation Accelerate Diabetic Bone Defect Repair.
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DOI: 10.1021/acsnano.5c08238
Abstract: Hyperglycemia-induced oxidative stress and inflammation critically impair diabetic bone defect repair. Here, a radially oriented microchannel scaffold (D-GSH@QZ) was developed via a directional freezing technique integrated with photo-cross-linking strategies. The scaffold was fabricated from gelatin… read more here.
Keywords: repair; pathological microenvironment; bone; bone defect ... See more keywords
Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes
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DOI: 10.1155/2022/2650342
Abstract: Type 1 diabetes is associated with complications affecting muscle and bone, with diabetic bone disease and diabetic myopathy becoming increasingly reported in the past few decades. This review is aimed at succinctly reviewing the literature… read more here.
Keywords: disease diabetic; diabetic bone; bone; type diabetes ... See more keywords
A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment
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DOI: 10.3389/fendo.2022.1052592
Abstract: Recently, the increasing prevalence of diabetes mellitus has made it a major chronic illness which poses a substantial threat to human health. The prevalence of osteoporosis among patients with diabetes mellitus has grown considerably. Diabetic… read more here.
Keywords: diabetic bone; review; bone; diabetes mellitus ... See more keywords
Dysfunction of macrophages leads to diabetic bone regeneration deficiency
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DOI: 10.3389/fimmu.2022.990457
Abstract: Insufficient bone matrix formation caused by diabetic chronic inflammation can result in bone nonunion, which is perceived as a worldwide epidemic, with a substantial socioeconomic and public health burden. Macrophages in microenvironment orchestrate the inflammation… read more here.
Keywords: regeneration; diabetic bone; bone; dysfunction macrophages ... See more keywords