Ipriflavone as a non‐steroidal glucocorticoid receptor antagonist ameliorates diabetic cognitive impairment in mice
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13572
Abstract: Diabetic cognitive impairment (DCI) is a common diabetic complication with hallmarks of loss of learning ability and disorders of memory and behavior. Glucocorticoid receptor (GR) dysfunction is a main reason for neuronal impairment in brain… read more here.
Keywords: antagonist; impairment; diabetic cognitive; cognitive impairment ... See more keywords
Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-20-0321
Abstract: Earlier, it was shown that reversing the downregulation of neuritin expression in the brain improves central neuropathy in diabetic rats. We investigated the protective mechanism of neuritin in diabetic cognitive dysfunction via astrocytes. Further, the… read more here.
Keywords: astrogliosis; dysfunction; jak2 stat3; cognitive dysfunction ... See more keywords
Diabetic Cognitive Dysfunction: From Bench to Clinic.
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DOI: 10.2174/1871530319666190206225635
Abstract: Type 2 diabetes increases the risk of developing cognitive dysfunction in the elderly in the form of short-term memory and executive function impairment. Genetic and diet-induced models of type 2 diabetes further support this link,… read more here.
Keywords: diabetic cognitive; dysfunction; cognitive dysfunction; type diabetes ... See more keywords
2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione Ameliorates Diabetic Cognitive Impairment Through Inhibiting Hif3α and Apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.708141
Abstract: Diabetes mellitus (DM) is an independent risk factor for cognitive impairment. Although the etiology of diabetic cognitive impairment is complex and multifactorial, the hippocampus neuronal apoptosis is recognized as a main cause of diabetes-induced cognitive… read more here.
Keywords: apoptosis; mice; diabetic cognitive; impairment ... See more keywords
Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia
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DOI: 10.3390/antiox12010074
Abstract: The present study was conducted to evaluate the effect of genipin (GEN) on the microglia of diabetic cognitive impairment and explore its potential mechanism. Diabetic mice were induced by STZ/HFD, while GEN was intragastrically and… read more here.
Keywords: mfn1; lipid accumulation; diabetic cognitive; cognitive impairment ... See more keywords
Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz
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DOI: 10.3390/ph16010050
Abstract: Diabetic cognitive dysfunction (DCD) is the decline in memory, learning, and executive function caused by diabetes. Although its pathogenesis is unclear, molecular biologists have proposed various hypotheses, including insulin resistance, amyloid β hypothesis, tau protein… read more here.
Keywords: hand mazz; cognitive dysfunction; erigeron breviscapus; dcd ... See more keywords