Role of microglia-neuron interactions in diabetic encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2017.12.005
Abstract: In the central nervous system, the primary immune cells, the microglia, prevent pathogenic invasion as the first line of defense. Microglial energy consumption is dependent on their degree of activity. Microglia express transporters for the… read more here.
Keywords: role microglia; diabetic encephalopathy; neuron interactions; microglia neuron ... See more keywords
Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted metabolomics analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113652
Abstract: Diabetic encephalopathy (DE) is a severe diabetic complication with cognitive dysfunction. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese formula, is effective for the treatment of diabetes mellitus and Alzheimer's disease in clinical practices, however, the… read more here.
Keywords: diabetic encephalopathy; huang lian; analysis; lian jie ... See more keywords
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Pain"
DOI: 10.1177/1744806921996101
Abstract: Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly occurring in the elderly patients. Berberine (BBR) is an isoquinoline alkaloids extracted from Coptis chinensis that is applied in the treatment of diabetes clinically.… read more here.
Keywords: rock pathway; diabetic encephalopathy; rho rock;
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.0823
Abstract: Diabetic Encephalopathy (DE) is one of the complications of diabetes mellitus (DM) in the central nervous system. Up to now, the mechanisms of DE are not fully discussed by the field. Autophagy is an intracellular… read more here.
Keywords: insights potential; potential therapeutic; diabetic encephalopathy; mechanistic insights ... See more keywords
Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins
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DOI: 10.32598/bcn.11.6.1657.1
Abstract: Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments associated with hippocampal degenerative changes, including the neurodegenerative process and decreased number of living cells. Mitochondrial diabetes (MD) appears following activation of mutant mitochondrial… read more here.
Keywords: diabetic encephalopathy; encephalopathy affecting; transport proteins; affecting mitochondria ... See more keywords
Analysis of Metabolic Alterations Related to Pathogenic Process of Diabetic Encephalopathy Rats
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00527
Abstract: Diabetic encephalopathy (DE) is a diabetic complication characterized by alterations in cognitive function and nervous system structure. The pathogenic transition from hyperglycemia to DE is a long-term process accompanied by multiple metabolic disorders. Exploring time-dependent… read more here.
Keywords: diabetic encephalopathy; metabolic alterations; analysis metabolic; metabolic changes ... See more keywords
Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021196
Abstract: Patients affected by diabetes mellitus (DM) show diabetic encephalopathy with an increased risk of cognitive deficits, dementia and Alzheimer’s disease, but the mechanisms are not fully explored. In the male animal models of DM, the… read more here.
Keywords: diabetes mellitus; model type; experimental model; diabetic encephalopathy ... See more keywords
PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032021
Abstract: Diabetic encephalopathy (DE) is an inflammation-associated diabetes mellitus (DM) complication. Inflammation and coagulation are linked and are both potentially modulated by inhibiting the thrombin cellular protease-activated receptor 1 (PAR1). Our aim was to study whether… read more here.
Keywords: model; diabetic encephalopathy; thrombin; parin5 novel ... See more keywords
miR-130b regulates PTEN to activate the PI3K/Akt signaling pathway and attenuate oxidative stress-induced injury in diabetic encephalopathy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2021.4974
Abstract: Diabetic encephalopathy (DE) is one of the main chronic complications of diabetes, and is characterized by cognitive defects. MicroRNAs (miRNAs/miRs) are widely involved in the development of diabetes-related complications. The present study evaluated the role… read more here.
Keywords: diabetic encephalopathy; akt signaling; pi3k akt; mir 130b ... See more keywords
Interleukin 17A deficiency alleviates neuroinflammation and cognitive impairment in an experimental model of diabetic encephalopathy
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.339490
Abstract: Interleukin 17A (IL-17A) was previously shown to be a key pro-inflammatory factor in diabetes mellitus and associated complications. However, the role of IL-17A in diabetic encephalopathy remains poorly understood. In this study, we established a… read more here.
Keywords: model diabetic; 17a deficiency; neuroinflammation cognitive; interleukin 17a ... See more keywords