Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart
Sign Up to like & getrecommendations! Published in 2017 at "Heart Failure Reviews"
DOI: 10.1007/s10741-017-9663-y
Abstract: The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart… read more here.
Keywords: heart; dysfunction diabetic; diabetic heart; contractile dysfunction ... See more keywords
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy
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DOI: 10.1016/j.arr.2021.101338
Abstract: Association of diabetes with an elevated risk of cardiac failure has been clinically evident. Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction that produces the cardiac muscle-specific microvascular complication, clinically termed as… read more here.
Keywords: autophagy diabetic; diabetic heart; autophagy; diabetic cardiomyopathy ... See more keywords
p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.01.028
Abstract: p53 is an important modulator of stem cell fate, but its role in cardiac progenitor cells (CPCs) is unknown. Here, we tested the effects of a single extra-copy of p53 on the function of CPCs… read more here.
Keywords: progenitor cells; diabetic heart; cpcs; cardiac progenitor ... See more keywords
Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20160916
Abstract: Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive the process of fibrotic events in the diabetic heart are still… read more here.
Keywords: heart; mir 15a; diabetic heart; fibrotic remodelling ... See more keywords
Diabetic cardiomyopathy was attenuated by cinnamon treatment through the inhibition of fibro-inflammatory response and ventricular hypertrophy in diabetic rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14206
Abstract: Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes that emphasizes the urgency of developing new drug therapies. With an illustrious history in traditional medicine to improve diabetes, cinnamon has been shown to possess blood… read more here.
Keywords: diabetic rats; cinnamon extract; blood; diabetic heart ... See more keywords
Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/2719252
Abstract: Luteolin has been reported to attenuate ischemia/reperfusion (I/R) injury in the diabetic heart through endothelial nitric oxide synthase- (eNOS-) related antioxidative response. Though the nuclear factor erythroid 2-related factor 2 (Nrf2) is regarded as a… read more here.
Keywords: diabetic heart; injury diabetic; luteolin; ischemia ... See more keywords
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl− Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart
Sign Up to like & getrecommendations! Published in 2019 at "Mediators of Inflammation"
DOI: 10.1155/2019/7583760
Abstract: Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical problems associated with ion imbalance. However, the mechanism of ion imbalance mediated by cardioplegia and a diabetic heart is largely unclear. We hypothesized that ion… read more here.
Keywords: heart; diabetic heart; cardioplegia induced; induced arrest ... See more keywords
Abstract 14981: Altered Gene Expression in Diabetic Heart Failure Patients
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DOI: 10.1161/circ.142.suppl_3.14981
Abstract: Introduction: Diabetes and heart failure are very closely associated. Diabetes patients have an increased risk of developing heart failure and heart failure patients are at higher risk of developing diabetes. Changes occur in myocardial glucose… read more here.
Keywords: heart; failure patients; diabetic heart; heart failure ... See more keywords
Basic Mechanisms of Diabetic Heart Disease.
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DOI: 10.1161/circresaha.120.315913
Abstract: Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating in terms of prognosis is heart failure. Indeed, the increasing global prevalence of diabetes mellitus and an aging… read more here.
Keywords: heart; diabetic heart; basic mechanisms; diabetes mellitus ... See more keywords
Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries
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DOI: 10.1161/circulationaha.122.059304
Abstract: Background: Diabetic heart dysfunction is a common complication of diabetes. Cell death is a core event that leads to diabetic heart dysfunction. However, the time sequence of cell death pathways and the precise time to… read more here.
Keywords: cell death; dysfunction; heart; receptor ... See more keywords
Multi-modality cardiac imaging in the management of diabetic heart disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1043711
Abstract: Diabetic heart disease is a major healthcare problem. Patients with diabetes show an excess of death from cardiovascular causes, twice as high as the general population and those with diabetes type 1 and longer duration… read more here.
Keywords: cardiac imaging; disease; heart; medicine ... See more keywords