Pretreatment with vildagliptin boosts ischemic-postconditioning effects on cardioprotection and expression profile of genes regulating autophagy and mitochondrial fission/fusion in diabetic heart with reperfusion injury
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DOI: 10.1007/s00210-019-01660-z
Abstract: The burden of myocardial ischemia/reperfusion (IR) injury is 2–3-folds higher in diabetic patients, so protecting diabetic hearts is clinically important. Here, we investigated the effect of combinational therapy with vildagliptin and ischemic postconditioning (IPostC) on… read more here.
Keywords: diabetic hearts; vildagliptin; reperfusion; expression ... See more keywords
Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts
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DOI: 10.14814/phy2.13741
Abstract: To explore mechanisms by which SGLT2 inhibitors protect diabetic hearts from heart failure, we examined the effect of empagliflozin (Empa) on the ultrastructure of cardiomyocytes in the noninfarcted region of the diabetic heart after myocardial… read more here.
Keywords: diabetic hearts; reduction mitochondrial; mitochondrial size; number ... See more keywords